ArticleJournal of pharmacokinetics and pharmacodynamics2011
Development of appropriate equations for physiologically based pharmacokinetic modeling of permeability-limited and flow-limited transport.
Article in Journal of pharmacokinetics and pharmacodynamics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
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- Haloperidol dopamine receptor occupancy and antagonism correspond to delirium agitation scores and EPS risk: A PBPK-PD modeling analysis.Journal of psychopharmacology (Oxford, England) · 2025Article
- Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling of Nanomaterials.ACS pharmacology & translational science · 2024Review
- A Complete Extension of Classical Hepatic Clearance Models Using Fractional Distribution Parameter fJournal of pharmaceutical sciences · 2024Article
- Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Environmental science & technology · 2022Article
- Consideration of Fractional Distribution Parameter fPharmaceutical research · 2022Article
- PBPK Modeling to Simulate the Fate of Compounds in Living Organisms.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Pharmacokinetics of 2-phenoxyethanol and its major metabolite, phenoxyacetic acid, after dermal and inhaled routes of exposure: application to development PBPK model in rats.Archives of toxicology · 2021Article
- Image-guided mathematical modeling for pharmacological evaluation of nanomaterials and monoclonal antibodies.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- Current Approaches and Techniques in Physiologically Based Pharmacokinetic (PBPK) Modelling of Nanomaterials.Nanomaterials (Basel, Switzerland) · 2020Review
- A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery.Computational and structural biotechnology journal · 2020Article
- Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling With mrgsolve: A Hands-On Tutorial.CPT: pharmacometrics & systems pharmacology · 2019Article
- Computational framework for predictive PBPK-PD-Tox simulations of opioids and antidotes.Journal of pharmacokinetics and pharmacodynamics · 2019Article
- Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding.Frontiers in pharmacology · 2019Article
- Comparison of distributed and compartmental models of drug disposition: assessment of tissue uptake kinetics.Journal of pharmacokinetics and pharmacodynamics · 2016Article
- Engineering challenges for instrumenting and controlling integrated organ-on-chip systems.IEEE transactions on bio-medical engineering · 2013Article
- Applications of minimal physiologically-based pharmacokinetic models.Journal of pharmacokinetics and pharmacodynamics · 2012Article
- Use of partition coefficients in flow-limited physiologically-based pharmacokinetic modeling.Journal of pharmacokinetics and pharmacodynamics · 2012Article
- Physiologically based pharmacokinetic tissue compartment model selection in drug development and risk assessment.Journal of pharmaceutical sciences · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although the implementation of a flow-limited, well-stirred tank (WST) single-compartment tissue model in pharmacokinetics and toxicokinetics is widespread, its use is not always justified biophysically or physiologically. The WST model introduces a loss of biophysical detail, specifically the vascular space, which is present in the standard permeability-limited two-subcompartment (PLT) tissue model. To address this loss of detail when evaluating the in vivo kinetics of drugs, toxins, nutrients, and endogenous metabolites, a novel set of physiologically based pharmacokinetic tissue compartment equations is developed through application of an asymptotic approximation to a two-region vascular-extravascular system to arrive at a permeability-limited two-region asymptotically reduced (P-TAR) model and a flow-limited (F-TAR) model. Development of the TAR modeling approach illustrates the importance of relative timescales in PBPK tissue compartment model selection and the conditions under which improved biophysical realism is advantageous. In the permeability-limited regime, the TAR model formulations enable drug or toxicant concentration to be modeled in the vascular and extravascular spaces equivalent to the PLT tissue model while invoking only one state variable to represent the vascular and extravascular spaces. In the flow-limited regime, the F-TAR model is more biophysically realistic than the WST model because it maintains the anatomical distinction between the vascular and extravascular spaces, and hence offers greater pharmacological and physiological insight than the WST model, without introducing additional computational complexity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.