Trial reportInternational orthopaedics2011
First experiences with negative pressure wound therapy and instillation in the treatment of infected orthopaedic implants: a clinical observational study.
Trial report in International orthopaedics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of negative pressure wound therapy with instillation and dwell time (NPWTi-d) versus NPWT or standard of care in orthoplastic surgery: A systematic review and meta-analysis.International wound journal · 2023Pooled it
- Negative pressure wound therapy for seroma prevention and surgical incision treatment in spinal fracture care.International wound journal · 2016Trial
- Incisional negative pressure wound therapy after hemiarthroplasty for femoral neck fractures - reduction of wound complications.International wound journal · 2016Trial
- Negative pressure wound therapy to prevent seromas and treat surgical incisions after total hip arthroplasty.International orthopaedics · 2012Trial
- Long term experiences with negative pressure wound therapy in combination with polyhexanid solution instillation technique for treatment of posttraumatic infections and osteomyelitis.Langenbeck's archives of surgery · 2026Article
- The effect of post-operative continuous negative pressure therapy after debridement, antibiotics, and implant retention for acute periprosthetic joint infection.Journal of orthopaedic surgery and research · 2025Article
- Application and influence of four drain configurations on fluid dispersal and retrieval in a cadaveric canine wound infusion-retrieval system model.Veterinary surgery : VS · 2025Article
- Article
- Modified negative pressure wound therapy as an adjunct to antibiotics in the treatment of orthopaedic infected metalwork.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Article
- Experience with negative-pressure wound therapy with instillation in complex infected orthopaedic wounds.International wound journal · 2021Observational
- Is Negative Pressure Wound Therapy with Instillation Suitable for the Treatment of Acute Periprosthetic Hip Joint Infection?Journal of clinical medicine · 2021Article
- Negative pressure wound therapy with instillation and dwell time (NPWTi-d) with V. A. C. VeraFlo in traumatic, surgical, and chronic wounds-A helpful tool for decontamination and to prepare successful reconstruction.International wound journal · 2020Article
- Article
- Instillation negative pressure wound therapy: An effective approach for hardware salvage.International wound journal · 2020Article
- Successful Treatment of Driveline Infection with Vacuum-Assisted Closure Therapy and Instillation Therapy.The Thoracic and cardiovascular surgeon reports · 2020Article
- Instillation Negative Pressure Wound Therapy: A Role for Infected LVAD Salvage.Advances in wound care · 2019Article
- Negative pressure wound treatment with computer-controlled irrigation/instillation decreases bacterial load in contaminated wounds and facilitates wound closure.International wound journal · 2018Article
- Negative Pressure Wound Therapy with Instillation in the Septic Open Abdomen Utilizing a Modified Negative Pressure Therapy System.Annals of medicine and surgery (2012) · 2018Review
- Instillation Negative Pressure Wound Therapy: An Effective Tool for Complex Spine Wounds.Advances in wound care · 2018Article
- [Importance of wound irrigation solutions and fluids with antiseptic effects in therapy and prophylaxis : Update 2017].Der Unfallchirurg · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInfections associated with orthopaedic implants remain a serious complication. The main objective in acute infection control is component retention, whereas this option is usually not considered for chronic infections.
methodsThis multi-centre prospective, non-randomised observational study investigated one possible treatment option for implant retention in combination with negative pressure wound therapy with instillation (NPWTi). Thirty-two patients with an infected orthopaedic implant were analysed. Twenty-two patients had an acute infection (< 8 weeks after implantation) and ten patients had a chronic infection (> 8 weeks and < 36 weeks after implant placement). Polyhexanide was used as the instillation solution in 31 of the 32 cases.
resultsNineteen patients (86.4%) with an acute infection and eight patients (80%) with a chronic infection retained their implant at 4-6 months follow-up after treatment.
conclusionsOur study showed that NPWTi can be used as adjunctive therapy for salvage of acutely infected orthopaedic implants and may even be considered for early chronically infected implants.
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