Evidence map›Paper›PMID 21584262›Full record

ArticleNeural plasticity2010

Dendritic spines and development: towards a unifying model of spinogenesis--a present day review of Cajal's histological slides and drawings.

Pablo García-López, Virginia García-Marín, Miguel Freire

Abstract readBiographyHistorical Article
In one paragraph

Article in Neural plasticity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Introduction: What Are Dendritic Spines?Advances in neurobiology · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. The Subcortical-Allocortical- NeocorticalFrontiers in synaptic neuroscience · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. A fly's view of neuronal remodeling.Wiley interdisciplinary reviews. Developmental biology · 2016
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. S-nitrosation and neuronal plasticity.British journal of pharmacology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pablo García-LópezDepartment of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain.
Virginia García-Marín
Miguel Freire

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic spines receive the majority of excitatory connections in the central nervous system, and, thus, they are key structures in the regulation of neural activity. Hence, the cellular and molecular mechanisms underlying their generation and plasticity, both during development and in adulthood, are a matter of fundamental and practical interest. Indeed, a better understanding of these mechanisms should provide clues to the development of novel clinical therapies. Here, we present original results obtained from high-quality images of Cajal's histological preparations, stored at the Cajal Museum (Instituto Cajal, CSIC), obtained using extended focus imaging, three-dimensional reconstruction, and rendering. Based on the data available in the literature regarding the formation of dendritic spines during development and our results, we propose a unifying model for dendritic spine development.

Indexed as

Models, NeurologicalAnimalsCell DifferentiationDendritic SpinesHistory, 19th CenturyHistory, 20th CenturyHumansImage CytometryMedical IllustrationTissue Banks

Identifiers

PMID21584262
PMCPMC3091278

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.