ArticleJournal of parasitology research2011
Helminth parasites and the modulation of joint inflammation.
Article in Journal of parasitology research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Fasciola hepatica extract suppresses fibroblast-like synoviocytes in vitro and alleviates experimental arthritis.Advances in rheumatology (London, England) · 2022Trial
- The influence of parasitic infection (Eimeria spp.) on bone and cartilage tissue in an animal model.Scientific reports · 2025Article
- Feature Paper in Oral Physiology and Pathology.Life (Basel, Switzerland) · 2024Article
- Recombinant Fasciola hepatica Fatty Acid Binding Protein as a Novel Anti-Inflammatory Biotherapeutic Drug in an Acute Gram-Negative Nonhuman Primate Sepsis Model.Microbiology spectrum · 2021Article
- Fasciola hepatica GST downregulates NF-κB pathway effectors and inflammatory cytokines while promoting survival in a mouse septic shock model.Scientific reports · 2019Article
- Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer.Investigational new drugs · 2019Article
- Schistosoma mansoni SmKI-1 serine protease inhibitor binds to elastase and impairs neutrophil function and inflammation.PLoS pathogens · 2018Article
- Immunoproteomics and Surfaceomics of the Adult TapewormFrontiers in immunology · 2018Article
- Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for Inflammatory Disease?PLoS pathogens · 2016Review
- Article
- Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins.BioMed research international · 2015Article
- Helminth parasites alter protection against Plasmodium infection.BioMed research international · 2014Review
- Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour?Pathogens and disease · 2013Review
- Helminth infections and host immune regulation.Clinical microbiology reviews · 2012Review
- Trichinella spiralis: shaping the immune response.Immunologic research · 2012Review
- Does helminth activation of toll-like receptors modulate immune response in multiple sclerosis patients?Frontiers in cellular and infection microbiology · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an urgent need to develop better therapeutics for autoimmune and autoinflammatory diseases, of which musculoskeletal disorders such as rheumatoid arthritis are particularly prevalent and debilitating. Helminth parasites are accomplished masters at modifying their hosts' immune activity, and so attention has focused on rodent-helminth model systems to uncover the workings of the mammalian immune response to metazoan parasites, with the hope of revealing molecules and/or mechanisms that can be translated into better treatments for human autoimmune and idiopathic disorders. Substantial proof-of-principal data supporting the concept that infection with helminth parasites can reduce the severity of concomitant disease has been amassed from models of mucosal inflammation. Indeed, infection with helminth parasites has been tried as a therapy in inflammatory bowel disease, and there are case reports relating to other conditions (e.g., autism); however, the impact of infection with parasitic helminths on musculoskeletal diseases has not been extensively studied. Here, we present the view that such a strategy should be applied to the amelioration of joint inflammation and review the literature that supports this contention.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.