ArticleNeurology international2010
Diagnosis of brain death.
Article in Neurology international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Guidelines for the assessment and acceptance of potential brain-dead organ donors.Revista Brasileira de terapia intensiva · 2016Guideline
- Review
- Computed Tomography Angiography as Ancillary Testing for Death Determination by Neurologic Criteria: A Technical Review.Tomography (Ann Arbor, Mich.) · 2024Review
- Review
- Computed Tomography Angiography (CTA) in Selected Scenarios with Risk of Possible False-Positive or False-Negative Conclusions in Diagnosing Brain Death.Life (Basel, Switzerland) · 2022Review
- Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model.Biomedical journal · 2022Article
- Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system.Journal of biomedical science · 2020Article
- Analysis of brain death declaration process and its impact on organ donation in a reference trauma center.Einstein (Sao Paulo, Brazil) · 2020Observational
- The role of cervical color Doppler ultrasound in the diagnosis of brain death.Neuroradiology · 2019Article
- Delays in Brain Death Certification in an Opt-out Deceased Organ Donation System: Causes, Ethical Problems, and Avoidance.Asian bioethics review · 2018Article
- The Role of Neuroimaging in the Determination of Brain Death.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
- DHA-supplemented diet increases the survival of rats following asphyxia-induced cardiac arrest and cardiopulmonary bypass resuscitation.Scientific reports · 2016Article
- Clinical utility of arterial spin-labeling as a confirmatory test for suspected brain death.AJNR. American journal of neuroradiology · 2015Article
- Gadolinium-enhanced magnetic resonance angiography in brain death.Scientific reports · 2014Article
- Is brain death diagnosis in newborns feasible?Hippokratia · 2012Article
- Temperature and brain death determination: need for updated criteria.Neurology international · 2010Article
- CT angiography as a confirmatory test in diagnosis of brain death: comparison between three scoring systems.Diagnostic and interventional radiology (Ankara, Turkey)Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain death (BD) should be understood as the ultimate clinical expression of a brain catastrophe characterized by a complete and irreversible neurological stoppage, recognized by irreversible coma, absent brainstem reflexes, and apnea. The most common pattern is manifested by an elevation of intracranial pressure to a point beyond the mean arterial pressure, and hence cerebral perfusion pressure falls and, as a result, no net cerebral blood flow is present, in due course leading to permanent cytotoxic injury of the intracranial neuronal tissue. A second mechanism is an intrinsic injury affecting the nervous tissue at a cellular level which, if extensive and unremitting, can also lead to BD. We review here the methodology of diagnosing death, based on finding any of the signs of death. The irreversible loss of cardio-circulatory and respiratory functions can cause death only when ischemia and anoxia are prolonged enough to produce an irreversible destruction of the brain. The sign of such loss of brain functions, that is to say BD diagnosis, is fully reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.