ArticleInternational journal of clinical and experimental pathology2011
Morphological heterogeneity of oral salivary gland carcinomas: a clinicopathologic study of 41 cases with long term follow-up emphasizing the overlapping spectrum of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
Article in International journal of clinical and experimental pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Pooled it
- Immunohistochemical Profile of Polymorphous Adenocarcinoma of Minor Salivary Gland: A Systematic Review and Meta-Analysis.Head and neck pathology · 2022Pooled it
- Expression of phosphohistone H3 and X-linked inhibitors of apoptosis-related proteins in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary glands.Scientific reports · 2025Article
- Immunohistochemical Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Salivary Gland Cancer: Correlation with the Biological Behavior.Diagnostics (Basel, Switzerland) · 2023Article
- Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Adenoid cystic carcinoma of palate: Report of a solid variant.Journal of oral and maxillofacial pathology : JOMFP · 2018Article
- Clear cell changes in salivary gland neoplasms: A 20-year retrospective study.Medicina oral, patologia oral y cirugia bucal · 2017Article
- Perineural Spread in Noncutaneous Head and Neck Cancer: New Insights into an Old Problem.Journal of neurological surgery. Part B, Skull base · 2016Review
- A case of mucoepidermoid carcinoma located in the left forearm of a middle-aged pregnant woman.International journal of clinical and experimental medicine · 2014Article
- Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.Interventional medicine & applied science · 2013Article
- Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists.Diagnostic pathology · 2013Review
- Salivary gland carcinomas.Oral and maxillofacial surgery · 2012Review
- A review: Immunological markers for malignant salivary gland tumors.Journal of oral biology and craniofacial researchReview
- Diagnostic reliability of c-KIT (CD117) in salivary gland tumours - A systematic review and meta-analysis.Journal of oral and maxillofacial pathology : JOMFPReview
- Polymorphous adenocarcinoma: A case report along with its characteristics and diagnostic challenges.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed 41 oral salivary gland carcinomas from consecutive 290 salivary gland carcinoma database (14%) with emphasis on the histological spectrum and clinical outcome of adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA). The cohort included 14 ACCs, 14 mucoepidermoid carcinomas (MECs), 8 PLGAs, 3 adenocarcinomas, not otherwise specified and 2 acinic cell carcinomas. Mean age was 48, 58 and 61 yrs for ACC, MEC and PLGA, respectively. Eight patients (19.5%) died of tumor at a mean interval of 66.5 months. ACC and PLGA showed similar mean age, gender distribution, predominant palatal localization, nodal metastasis, perineural invasion and MIB-1 index. However, ACC tended to show higher tumor stage and residual tumor (R1/R2) more frequently than PLGA, but this was statistically not significant. ACC and PLGA showed overlapping architectural patterns. However, ACCs displayed well organized basal-luminal differentiation, highlighted by CK5/CK7 immunostaining. In contrast, PLGA showed a disorganized histological and immunohistological pattern. C-Kit expression (CD117) was common in ACC, generally mirroring that of CK7 and virtually lacking in PLGA. Kaplan-Meier analysis demonstrated a similar clinical course for ACC and PLGA with 5 years survivals of 87% and 80%, respectively. Fluorescence in situ hybridization (FISH) performed on all 290 salivary carcinomas confirmed the specificity of the translocation t (11; 19) for MEC and its absence in all other carcinomas including ACC and PLGA. Our results emphasize the diversity of oral salivary gland carcinomas and the overlapping clinicopathological features of ACC and PLGA.
Indexed as
Identifiers
21577319PMC3093058W1547239093What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.