ArticleFrontiers in neuroscience2011
Acquisition of an olfactory associative task triggers a regionalized down-regulation of adult born neuron cell death.
Article in Frontiers in neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb.Cellular and molecular life sciences : CMLS · 2023Article
- Short-term availability of adult-born neurons for memory encoding.Nature communications · 2019Article
- Activity-Dependent Gene Expression in the Mammalian Olfactory Epithelium.Chemical senses · 2017Review
- Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury.Experimental neurology · 2016Review
- The type 3 adenylyl cyclase is required for the survival and maturation of newly generated granule cells in the olfactory bulb.PloS one · 2015Article
- How neurogenesis finds its place in a hardwired sensory system.Frontiers in neuroscience · 2014Review
- Context-driven activation of odor representations in the absence of olfactory stimuli in the olfactory bulb and piriform cortex.Frontiers in behavioral neuroscience · 2014Article
- Intranasal LPS-mediated Parkinson's model challenges the pathogenesis of nasal cavity and environmental toxins.PloS one · 2013Article
- Action of the noradrenergic system on adult-born cells is required for olfactory learning in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neurogenesis drives stimulus decorrelation in a model of the olfactory bulb.PLoS computational biology · 2012Article
- Cellular imaging and emerging technologies for adult neurogenesis research.Frontiers in neuroscience · 2012Article
- Reduced proliferation in the adult mouse subventricular zone increases survival of olfactory bulb interneurons.PloS one · 2012Article
- Newborn neurons in the olfactory bulb selected for long-term survival through olfactory learning are prematurely suppressed when the olfactory memory is erased.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Involvement of newborn neurons in olfactory associative learning? The operant or non-operant component of the task makes all the difference.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associative olfactory learning increased survival of adult born granule interneurons in the olfactory bulb (OB) at regions which are specific to the learned odorant. However, the mechanism shaping this odor-specific distribution of newborn neurons and its temporal relationship with the learning process are unknown. In the present study, using Bromodeoxyuridine or activated-caspase3 labeling, newborn and apoptotic cells respectively were mapped in the granule cell layer (GCL) of the OB, just before, during, and at the end of odor conditioning or pseudo-conditioning in adult mice. Results indicate that before and during training, when the task is not yet acquired, conditioned and pseudo-conditioned animals displayed the same density of newborn neurons. However, at the end of the conditioning, when the animals mastered the task, the density of newborn cells remained elevated in conditioned animals while it decreased in pseudo-conditioned animals suggesting newborn cell death in that group. Indeed, using Activated-Caspase3/BrdU co-labeling, we found that the proportion of newborn cells among dying cells was reduced in conditioned animals mastering the task compared to non-expert conditioned or pseudo-conditioned animals. The overall level of cell death did not change across training and was similar in conditioned and pseudo-conditioned groups, indicating that BrdU-positive cells were spared to the detriment of non-labeled cells. In addition, a fine analysis of cell distribution showed an uneven distribution of apoptotic cells, with lower densities in the medial part of the GCL where the density of newborn cells is high in conditioned animals. We conclude that acquisition of the task triggered the rescue of newborn neurons by a targeted regulation of cell death.
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