Evidence map›Paper›PMID 21577108›Full record

ReviewCurrent opinion in neurology2011

Movement disorders in paraneoplastic and autoimmune disease.

Jessica Panzer, Josep Dalmau

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  14. Article
  15. Neurological Complications in Patients with Systemic Lupus Erythematosus.Current neurology and neuroscience reports · 2019
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Hyperkinetic Movement Disorder Emergencies.Current neurology and neuroscience reports · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Jessica PanzerDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Josep Dalmau
University of Pennsylvania · US

Funding

Immunity to Brain Ma Proteins--A Remote Effect of CancerR01CA089054 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DALMAU, JOSEP O. · 2001 to 2011
$2.1M
Paraneoplastic Disorders of the CNS: Autoantigen ProfilingR01NS077851 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DALMAU, JOSEP O. · 2011 to 2015
$1.9M
Paraneoplastic Disorders of CNS: Autoantigen ProfilingR01CA107192 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DALMAU, JOSEP O. · 2004 to 2007
$1.2M
Synaptic autoimmunity in disorders of memory, behavior, cognition and psychosisRC1NS068204 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BALICE-GORDON, RITA J., DALMAU, JOSEP O. · 2009 to 2010
$965k
Immunity to brain Ma proteins: A remote effect of cancerR56CA089054 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DALMAU, JOSEP O. · 2007 to 2007
$259k
NCI NIH HHS R01 CA089054NCI NIH HHS R01 CA107192NCI NIH HHS R01CA89054NCI NIH HHS R56 CA089054NINDS NIH HHS 1RC1NS068204-01NINDS NIH HHS R01 NS077851NINDS NIH HHS RC1 NS068204
6 · The paper itself

Abstract

purpose of reviewThe most relevant advances in immune-mediated movement disorders are described, with emphasis on the clinical--immunological associations, novel antigens, and treatment. RECENT

findingsMany movement disorders previously considered idiopathic or degenerative are now recognized as immune-mediated. Some disorders are paraneoplastic, such as anti-CRMP5-associated chorea, anti-Ma2 hypokinesis and rigidity, anti-Yo cerebellar ataxia and tremor, and anti-Hu ataxia and pesudoathetosis. Other disorders such as Sydenham's chorea, or chorea related to systemic lupus erythematosus and antiphospholipid syndrome occur in association with multiple antibodies, are not paraneoplastic, and are triggered by molecular mimicry or unknown mechanisms. Recent studies have revealed a new category of disorders that can be paraneoplastic or not, and associate with antibodies against cell-surface or synaptic proteins. They include anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, which may cause dyskinesias, chorea, ballismus or dystonia (NMDAR antibodies), the spectrum of Stiff-person syndrome/muscle rigidity (glutamic acid decarboxylase, amphiphysin, GABA(A)-receptor-associated protein, or glycine receptor antibodies), neuromyotonia (Caspr2 antibodies), and opsoclonus--myoclonus--ataxia (unknown antigens). SUMMARY: Neurologists should be aware that many movement disorders are immune-mediated. Recognition of these disorders is important because it may lead to the diagnosis of an occult cancer, and a substantial number of patients, mainly those with antibodies to cell-surface or synaptic proteins, respond to immunotherapy.

Indexed as

AutoantibodiesAutoimmune DiseasesHumansImmunotherapyMovement DisordersParaneoplastic Syndromes, Nervous SystemAutoantibodies

Identifiers

PMID21577108
PMCPMC3705177
OpenAlexW2077616076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.