ArticleObesity facts2011
Genetic and environmental dissections of sub-phenotypes of metabolic syndrome in the Chinese population: a twin-based heritability study.
Article in Obesity facts, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Heritability of the Severity of the Metabolic Syndrome in Whites and Blacks in 3 Large Cohorts.Circulation. Cardiovascular genetics · 2017Pooled it
- Article
- Bivariate genome-wide association study (GWAS) of body mass index and blood pressure phenotypes in northern Chinese twins.PloS one · 2021Article
- Heritability and genome-wide association analyses of fasting plasma glucose in Chinese adult twins.BMC genomics · 2020Article
- Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis.Frontiers in genetics · 2018Article
- Heritability and Genome-Wide Association Study of Plasma Cholesterol in Chinese Adult Twins.Frontiers in endocrinology · 2018Article
- Genetic and Environmental Regulation on Longitudinal Change of Metabolic Phenotypes in Danish and Chinese Adult Twins.PloS one · 2016Article
- Longitudinal Investigation into Genetics in the Conservation of Metabolic Phenotypes in Danish and Chinese Twins.PloS one · 2016Article
- Associations of Body Composition Measurements with Serum Lipid, Glucose and Insulin Profile: A Chinese Twin Study.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe perform a comprehensive heritability study on multiple phenotypes related to metabolic syndrome using Chinese twins to assess the genetic and environmental effects in determining the variation and covariation of the phenotypes in the Chinese population.
methodsThe studied sample contains 654 twins collected in the Qingdao municipality. A total of 10 phenotypes covering anthropometric measurements, plasma glucose levels, lipids, blood pressures etc. were examined. Univariate and bivariate structural equation models were fitted for assessing the genetic and environmental contributions.
resultsThe AE model combining additive genetic (A) and unique environmental (E) factors produced the best fit for all phenotypes except for triglyceride. Modest to high heritability estimates were obtained in univariate analysis ranging from 0.5 for total cholesterol to 0.78 for weight. The bivariate model estimated high genetic correlations between systolic and diastolic blood pressures, between total cholesterol and low density lipoprotein cholesterol, modest genetic correlations between BMI and blood pressures. No significant common environmental correlation was found between any pair of the phenotypes.
conclusionsOur results showed significant genetic contributions to the sub-phenotypes of metabolic syndrome. Although pleiotropic genetic control may exist for some physiologically similar phenotypes, our results do not support a common genetic mechanism among the phenotypes covered in our study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.