ReviewCurrent problems in dermatology2011
The role of regulatory T cells in atopic dermatitis.
Review in Current problems in dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- The role of probiotics in the treatment of adult atopic dermatitis: a meta-analysis of randomized controlled trials.Journal of health, population, and nutrition · 2022Pooled it
- MicroRNAs in atopic dermatitis: A systematic review.Journal of cellular and molecular medicine · 2020Pooled it
- Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis.Nature communications · 2026Article
- Pediatric Atopic Dermatitis Exhibits Distinctive Patterns in JAK/STAT Pathway Activation and CD6-ALCAM Signaling.Immune network · 2025Article
- The Role of MicroRNA in the Pathogenesis of Atopic Dermatitis.International journal of molecular sciences · 2025Review
- Immunomodulating Effects of Heat-KilledVeterinary sciences · 2025Article
- Regulatory T cells and their role in allergic disease.Allergy · 2025Review
- The immunobiology and therapeutic potential of regulatory T cells in autoimmune diseases and allergic diseases.Frontiers in immunology · 2025Review
- Medicinal chemistry perspective of JAK inhibitors: synthesis, biological profile, selectivity, and structure activity relationship.Molecular diversity · 2024Review
- Neutrophils in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2024Review
- Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis.Journal of proteome research · 2024Article
- In utero or early-in-life exposure to antibiotics and the risk of childhood atopic dermatitis, a population-based cohort study.The British journal of dermatology · 2024Article
- Altered Gene Expression of IL-35 and IL-36α in the Skin of Patients with Atopic Dermatitis.International journal of molecular sciences · 2023Article
- Review
- Atopic Dermatitis: Disease Features, Therapeutic Options, and a Multidisciplinary Approach.Life (Basel, Switzerland) · 2023Review
- Evaluation of Leukocytes, B and T Lymphocytes, and expression of CD200 and CD23 on B lymphocytes in Patients with Atopic Dermatitis on Dupilumab Therapy-Pilot Study.Dermatology and therapy · 2023Article
- Osteopontin and Regulatory T Cells in Effector Phase of Allergic Contact Dermatitis.Journal of clinical medicine · 2023Article
- Association of KIR2DL5, KIR2DS5, and KIR2DS1 allelic variation and atopic dermatitis.Scientific reports · 2023Article
- Mechanism underlying polyvalent IgG-induced regulatory T cell activation and its clinical application: Anti-idiotypic regulatory T cell theory for immune tolerance.Frontiers in immunology · 2023Review
- KIR Allelic Variation and the Remission of Atopic Dermatitis Over Time.ImmunoHorizons · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Regulatory T (T(reg)) cells play a pivotal role in immune suppression and are integral to the control of allergic responses. The chronic inflammatory skin condition atopic dermatitis (AD) is severest in patients who are sensitized to allergens from diverse sources including foods, pollens and animal danders, as well as skin-colonizing organisms. These individuals typically present with eczematous skin eruptions in early childhood, and evolution of the disease is thought to reflect an underlying dysregulated T-cell response to allergens that manifests as a Th2 response. Studying T(reg) cells in the context of AD from infancy into adulthood could yield insight into their role in disease pathogenesis and reveal new strategies for exploiting these cells for therapeutic purposes. Such studies are challenging in humans owing to the heterogeneous nature of T(reg) cells, lack of a reliable surface marker, and the paucity of knowledge surrounding the emergence of specialized T cells in early life. Moreover, the blurred distinction between activated effector T cells and T(reg) cells further complicates studies in the context of inflammatory disorders such as AD. There is emerging evidence to suggest that T(reg) cells can convert to Th2 cells and that this pathway is bidirectional. This phenomenon may be a double-edged sword with important implications not only for subverting T(reg) cells in disease, but also for potential treatments designed to amplify these cells in order to suppress the allergic inflammatory cascade in AD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.