ArticleInfection and immunity1990
In vivo activation of macrophage oxidative burst activity by cytokines and amphotericin B.
Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- Review
- Antifungal Drugs Influence Neutrophil Effector Functions.Antimicrobial agents and chemotherapy · 2019Article
- Metallothioneins: Emerging Modulators in Immunity and Infection.International journal of molecular sciences · 2017Review
- Cellular immune activation in cerebrospinal fluid from ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome.The Journal of infectious diseases · 2015Observational
- Extracellular superoxide dismutase protects Histoplasma yeast cells from host-derived oxidative stress.PLoS pathogens · 2012Article
- It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug.Frontiers in microbiology · 2012Article
- Leishmania RNA virus: when the host pays the toll.Frontiers in cellular and infection microbiology · 2012Review
- Enhancement of a TH1 immune response in amphotericin B-treated mucocutaneous leishmaniasis.Journal of biomedicine & biotechnology · 2007Article
- Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.Antimicrobial agents and chemotherapy · 2005Article
- Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection.Antimicrobial agents and chemotherapy · 2004Article
- Immunoenhancement combined with amphotericin B as treatment for experimental visceral leishmaniasis.Antimicrobial agents and chemotherapy · 2003Article
- Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2002Article
- Reduction of no synthase expression and tumor necrosis factor alpha production in macrophages by amphotericin B lipid carriers.Antimicrobial agents and chemotherapy · 2001Article
- Therapeutic efficacy of human macrophage colony-stimulating factor, used alone and in combination with antifungal agents, in mice with systemic Candida albicans infection.Antimicrobial agents and chemotherapy · 2000Article
- Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis.Infection and immunity · 2000Article
- Amphotericin B and fluconazole affect cellular charge, macrophage phagocytosis, and cellular morphology of Cryptococcus neoformans at subinhibitory concentrations.Antimicrobial agents and chemotherapy · 1999Article
- Different susceptibilities of yeasts and conidia of Penicillium marneffei to nitric oxide (NO)-mediated fungicidal activity of murine macrophages.Clinical and experimental immunology · 1998Article
- Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals.Journal of virology · 1997Article
- Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B.Antimicrobial agents and chemotherapy · 1997Article
- Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum.Infection and immunity · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in macrophage oxidative burst activity following in vivo administration of recombinant murine gamma interferon (IFN-gamma), recombinant murine tumor necrosis factor alpha, and the antifungal antibiotic amphotericin B were investigated. Mice were given intraperitoneal injections of these agents alone and in combination, and the oxidative responses of their resident peritoneal macrophages to challenge with Histoplasma capsulatum or zymosan particles were measured 1 to 5 days later. Various degrees of enhanced oxidative burst activity were achieved following treatment with each agent. However, a synergistic response was observed only when mice were treated with the combination of recombinant murine IFN-gamma and amphotericin B. These results not only confirm the dual role of amphotericin as an antifungal agent and as an immunomodulator but also suggest that IFN-gamma may serve as a useful adjunct in the treatment of intracellular fungal infections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.