Evidence map›Paper›PMID 21576679›Full record

ReviewCirculation2011

Epigenetic modifications: basic mechanisms and role in cardiovascular disease.

Diane E Handy, Rita Castro, Joseph Loscalzo

Abstract readReview
In one paragraph

Review in Circulation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 478 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
478citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

478 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. The Epigenetic Horizon: New Molecular Perspectives.International journal of molecular sciences · 2026
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

418 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Diane E HandyCardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.
Rita Castro
Joseph Loscalzo

Funding

Tissue AnalysesP01HL048743 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 1992 to 2014
$26.3M
Redox regulation in Endothelial Progenitor CellsP01HL081587 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALSH, KENNETH · 2005 to 2015
$21.5M
Single Molecule Analysis of Sickle Erythrocyte Adhesion in Sickle Cell DiseaseU54HL070819 · NHLBI · BOSTON MEDICAL CENTER · PI LEOPOLD, JANE A · 2003 to 2011
$12.5M
GPx-3 and Peroxide Flux in the Endothelial CellR37HL061795 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2007 to 2016
$4.3M
PLATELET DERIVED REACTIVE OXYGEN SPECIES AND PLAQUER01HL061795 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 1998 to 2006
$1.6M
STRUCTURAL CHARACTERIZATION OF THE APOPROTEIN E RECEPTORR01HL028178 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI INNERARITY, THOMAS L. · 1986 to 1988
–
NHLBI PROTEOMICS INITIATIVE-N01HV28178N01HV028178 · HV · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2002 to 2006
–
NHLBI NIH HHS HL48743NHLBI NIH HHS HL61795NHLBI NIH HHS HL70819NHLBI NIH HHS HL81587NHLBI NIH HHS N01 HV028178NHLBI NIH HHS P01 HL048743NHLBI NIH HHS P01 HL081587NHLBI NIH HHS R01 HL061795NHLBI NIH HHS R37 HL061795NHLBI NIH HHS U54 HL070819
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiovascular DiseasesDNA MethylationEpigenesis, GeneticHistonesHomocysteineHumansHistonesHomocysteine

Identifiers

PMID21576679
PMCPMC3107542

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.