ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 82 citations in OpenAlex.
- Curtailment of Toll-like receptor signalling and cytokine production in dendritic cells by secreted products of Heligmosomoides polygyrus.PLoS pathogens · 2026Article
- Paragonimiasis Diagnosed Through Detection of Parasitic Ova in Pleural Effusion: A Clinical Case Report.Respirology case reports · 2025Article
- The Impact of Helminth Coinfection on Innate and Adaptive Immune Resistance and Disease Tolerance during Toxoplasmosis.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Tissue-specific immunity in helminth infections.Mucosal immunology · 2022Review
- The Gastrointestinal HelminthFrontiers in immunology · 2020Article
- Differential Sensitivity of Myeloid and Lymphoid Cell Populations to Apoptosis in Peritoneal Cavity of Mice with Model LarvalHelminthologia · 2019Article
- Worms: Pernicious parasites or allies against allergies?Parasite immunology · 2019Review
- Dendritic Cell-Mediated Th2 Immunity and Immune Disorders.International journal of molecular sciences · 2019Review
- Control of TNature communications · 2018Article
- Helminth Infections Induce Tissue Tolerance Mitigating Immunopathology but Enhancing Microbial Pathogen Susceptibility.Frontiers in immunology · 2018Review
- Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.PLoS neglected tropical diseases · 2017Article
- Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10-Mediated Responses.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles.The Journal of experimental medicine · 2017Article
- Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.Frontiers in cellular and infection microbiology · 2017Article
- Functions of Murine Dendritic Cells.Immunity · 2016Review
- Regulation of the host immune system by helminth parasites.The Journal of allergy and clinical immunology · 2016Review
- Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths.Mucosal immunology · 2016Article
- Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the Gut.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Regulation of Th2 Cell Immunity by Dendritic Cells.Immune network · 2016Review
- Leukocyte homing, fate, and function are controlled by retinoic acid.Physiological reviews · 2015Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Gastrointestinal helminth infections are extremely prevalent in many human populations and are associated with downmodulated immune responsiveness. In the experimental model system of Heligmosomoides polygyrus, a chronic infection establishes in mice, accompanied by a modulated Th2 response and increased regulatory T cell (Treg) activity. To determine if dendritic cell (DC) populations in the lymph nodes draining the intestine are responsible for the regulatory effects of chronic infection, we first identified a population of CD11c(lo) nonplasmacytoid DCs that expand after chronic H. polygyrus infection. The CD11c(lo) DCs are underrepresented in magnetic bead-sorted preparations and spared from deletion in CD11c-diptheria toxin receptor mice. After infection, CD11c(lo) DCs did not express CD8, CD103, PDCA, or Siglec-H and were poorly responsive to TLR stimuli. In DC/T cell cocultures, CD11c(lo) DCs from naive and H. polygyrus-infected mice could process and present protein Ag, but induced lower levels of Ag-specific CD4(+) T cell proliferation and effector cytokine production, and generated higher percentages of Foxp3(+) T cells in the presence of TGF-β. Treg generation was also dependent on retinoic acid receptor signaling. In vivo, depletion of CD11c(hi) DCs further favored the dominance of the CD11c(lo) DC phenotype. After CD11c(hi) DC depletion, effector responses were inhibited dramatically, but the expansion in Treg numbers after H. polygyrus infection was barely compromised, showing a significantly higher regulatory/effector CD4(+) T cell ratio compared with that of CD11c(hi) DC-intact animals. Thus, the proregulatory environment of chronic intestinal helminth infection is associated with the in vivo predominance of a newly defined phenotype of CD11c(lo) tolerogenic DCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.