ArticleProceedings of the National Academy of Sciences of the United States of America2011
Role of mother's genes and environment in postpartum depression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biological and psychosocial predictors of postpartum depression: systematic review and call for integration.Annual review of clinical psychology · 2015Pooled it
- Developmental mediation of genetic variation in response to the Fast Track prevention program.Development and psychopathology · 2015Trial
- The mediating effect of family support in the relationship between socio-economic status and postpartum depressive symptoms.BMC public health · 2024Article
- Review
- Association of polymorphisms of calcium reabsorption genes SLC12A1, KCNJ1 and SLC8A1 with colorectal adenoma.Journal of cancer research and clinical oncology · 2023Article
- Risk Factors for Postpartum Depression Based on Genetic and Epigenetic Interactions.Molecular neurobiology · 2023Review
- Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy.Archives of gynecology and obstetrics · 2023Article
- Genetic predictors of cultural values variation between societies.Scientific reports · 2023Article
- Post-partum depression: From clinical understanding to preclinical assessments.Frontiers in psychiatry · 2023Review
- Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture.iScience · 2022Article
- A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility.Molecular psychiatry · 2022Review
- Article
- Neurobiology of peripartum mental illness.Handbook of clinical neurology · 2021Review
- Article
- The study protocol: Neuroendocrinology and (epi-) genetics of female reproductive transition phase mood disorder - an observational, longitudinal study from pregnancy to postpartum.BMC pregnancy and childbirth · 2020Article
- Is Postpartum Depression Different From Depression Occurring Outside of the Perinatal Period? A Review of the Evidence.Focus (American Psychiatric Publishing) · 2020Review
- Serotonin and motherhood: From molecules to mood.Frontiers in neuroendocrinology · 2019Review
- The dynamic serotonin system of the maternal brain.Archives of women's mental health · 2019Article
- Does education attenuate the genetic risk of obesity? Evidence from U.K. Twins.Economics and human biology · 2018Article
- The role of tryptophan metabolism in postpartum depression.Metabolic brain disease · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Most studies of human molecular genetics and social environment interactions on health have relied heavily on the classic diathesis-stress model that treats genetic variations and environments as being either "risky" or "protective." The biological susceptibility model posits that some individuals have greater genetic reactivity to stress, leading to worse outcomes in poor environments, but better outcomes in rich environments. Using a nontruncated measure of a chronic environmental stressor--socioeconomic status--measured by education, and two polymorphisms (5-HTTLPR and STin2 VNTR) of the serotonin transporter gene (5-HTT), we find strong evidence that some women are genetically more reactive to the environment, resulting in a crossover of risks of postpartum depression for the most reactive groups. We discuss how our approach and findings provide a framework for understanding some of the confusion in the gene-environment interaction literature on stress, 5-HTT, and depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.