ArticleProceedings of the National Academy of Sciences of the United States of America2011
Genetic modulation of horizontal cell number in the mouse retina.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 35 citations in OpenAlex.
- Cell numbers, cell ratios, and developmental plasticity in the rod pathway of the mouse retina.Journal of anatomy · 2023Review
- ISL1 controls pancreatic alpha cell fate and beta cell maturation.Cell & bioscience · 2023Article
- Neurog2 regulates Isl1 to modulate horizontal cell number.Development (Cambridge, England) · 2023Article
- What connectomics can learn from genomics.PLoS genetics · 2021Article
- Overexpression ofInternational journal of molecular sciences · 2021Article
- Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice.Neuron · 2020Article
- From random to regular: Variation in the patterning of retinal mosaics.The Journal of comparative neurology · 2020Review
- Using BXD mouse strains in vision research: A systems genetics approach.Molecular vision · 2020Review
- Dopaminergic amacrine cell number, plexus density, and dopamine content in the mouse retina: Strain differences and effects of Bax gene disruption.Experimental eye research · 2018Article
- Genetic Control of Rod Bipolar Cell Number in the Mouse Retina.Frontiers in neuroscience · 2018Article
- Article
- Axon Terminal Arbors of Retinal Horizontal Cells Lose Control.Frontiers in neural circuits · 2018Review
- Distribution differences of macular cones measured by AOSLO: Variation in slope from fovea to periphery more pronounced than differences in total cones.Vision research · 2017Article
- Genomic control of neuronal demographics in the retina.Progress in retinal and eye research · 2016Review
- Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice.Molecular neurobiology · 2016Article
- Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease.Frontiers in neuroanatomy · 2016Review
- The role of Islet-1 in cell specification, differentiation, and maintenance of phenotypes in the vertebrate neural retina.Neural regeneration research · 2015Article
- Design principles and developmental mechanisms underlying retinal mosaics.Biological reviews of the Cambridge Philosophical Society · 2015Review
- Retinal regeneration is facilitated by the presence of surviving neurons.Developmental neurobiology · 2014Article
- Sox2 regulates cholinergic amacrine cell positioning and dendritic stratification in the retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Neuronal populations display conspicuous variability in their size among individuals, but the genetic sources of this variation are largely undefined. We demonstrate a large and highly heritable variation in neuron number within the mouse retina, affecting a critical population of interneurons, the horizontal cells. Variation in the size of this population maps to the distal end of chromosome (Chr) 13, a region homologous to human Chr 5q11.1-11.2. This region contains two genes known to modulate retinal cell number. Using conditional knock-out mice, we demonstrate that one of these genes, the LIM homeodomain gene Islet-1 (Isl1), plays a role in regulating horizontal cell number. Genetic differences in Isl1 expression are high during the period of horizontal cell production, and cis-regulation of Isl1 expression within the retina is demonstrated directly. We identify a single nucleotide polymorphism in the 5' UTR of Isl1 that creates an E-box sequence as a candidate causal variant contributing to this variation in horizontal cell number.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.