Evidence map›Paper›PMID 21576147›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2011

Reframing placebo in research and practice.

Wayne B Jonas

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02681484 (Speech Guided Breathing), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02681484 nacompletednot on this map

Speech Guided Breathing: a Modality to Influence Cardiovascular Regulation and Health Perception in Hypertensive Patients?

TypeinterventionalSponsorKlinik ArlesheimRan2002 to 2008Enrolled31ConditionsHypertensionArmsAnthroposophic speech therapy
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 45 citations in OpenAlex.

  1. The Effects ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  2. Article
  3. The Case for Whole-Person Integrative Care.Medicina (Kaunas, Lithuania) · 2021
    Review
  4. Article
  5. Article
  6. Article
  7. Salutogenesis: the defining concept for a new healthcare system.Global advances in health and medicine · 2014
    Article
  8. Article
  9. Reevaluating the placebo effect in medical practice.Zeitschrift fur Psychologie · 2014
    Article
  10. Research methodology: choices, logistics, and challenges.Evidence-based complementary and alternative medicine : eCAM · 2014
    Article
  11. Article
  12. Placebo interventions, placebo effects and clinical practice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011
    Review
  13. Introduction to placebo effects in medicine: mechanisms and clinical implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Wayne B JonasSamueli Institute, 1737 King Street, Suite 600, Alexandria, VA 22314, USA. wjonas@siib.org
Samueli Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The terms 'placebo' and 'placebo effects' cause confusion among patients, practitioners and scientists. This confusion results in both the adoption of practices that have no evidence of specificity yet considerable risk (such as surgery for low back pain) or the elimination of clinical practices proven to facilitate healing because they are not 'better than placebo' (such as acupuncture for low back pain). In this article, I discuss these issues and introduce the concept of optimal healing environment as a framework for disentangling what is useful from placebo research for adopting into clinical practice in a manner that is ethical and evidence-based.

Indexed as

Placebo EffectResearch DesignClinical MedicineClinical Trials as TopicEvidence-Based MedicineHumansLearningSocial Behavior

Identifiers

PMID21576147
PMCPMC3130408
OpenAlexW2106764773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.