ArticleHuman reproduction (Oxford, England)2011
Intra-individual stability over time of standardized anti-Mullerian hormone in FMR1 premutation carriers.
Article in Human reproduction (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Fragile X premutation carrier screening in Pakistani preconception women in primary care consultation.BMC women's health · 2022Article
- Molecular Pathogenesis and Peripheral Monitoring of Adult Fragile X-Associated Syndromes.International journal of molecular sciences · 2021Review
- Ectopic expression of CGG-repeats alters ovarian response to gonadotropins and leads to infertility in a murine FMR1 premutation model.Human molecular genetics · 2021Article
- Are ovarian response and pregnancy rates similar in selected FMR1 premutated and mutated patients undergoing preimplantation genetic testing?Journal of assisted reproduction and genetics · 2020Article
- An explanation of the mechanisms underlying fragile X-associated premature ovarian insufficiency.Journal of assisted reproduction and genetics · 2020Article
- Early Identification of Fragile X Syndrome through Expanded Newborn Screening.Brain sciences · 2019Review
- Preimplantation genetic diagnosis versus prenatal diagnosis-decision-making among pregnant FMR1 premutation carriers.Journal of assisted reproduction and genetics · 2018Article
- Implications of thePediatrics · 2017Review
- Reproductive and gynecologic care of women with fragile X primary ovarian insufficiency (FXPOI).Menopause (New York, N.Y.) · 2016Article
- Is FMR1 CGG repeat length a predictor of in vitro fertilization stimulation response or outcome?Fertility and sterility · 2016Article
- Improving Health Education for Women Who Carry an FMR1 Premutation.Journal of genetic counseling · 2016Article
- AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level.Journal of assisted reproduction and genetics · 2014Article
- Maximizing the clinical utility of antimüllerian hormone testing in women's health.Current opinion in obstetrics & gynecology · 2014Review
- Intermediate CGG repeat length at the FMR1 locus is not associated with hormonal indicators of ovarian age.Menopause (New York, N.Y.) · 2014Article
- Approaches to identify genetic variants that influence the risk for onset of fragile X-associated primary ovarian insufficiency (FXPOI): a preliminary study.Frontiers in genetics · 2014Article
- Associated features in females with an FMR1 premutation.Journal of neurodevelopmental disorders · 2014Review
- The FMR1 gene, infertility, and reproductive decision-making: a review.Frontiers in genetics · 2014Review
- Health and reproductive experiences of women with an FMR1 premutation with and without fragile X premature ovarian insufficiency.Frontiers in genetics · 2014Article
- Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI).Journal of neurodevelopmental disorders · 2014Review
- Genomic markers of ovarian reserve.Seminars in reproductive medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCarriers of a premutation (CGG repeat length 55-200) in the fragile X mental retardation (FMR1) gene are at risk for primary ovarian insufficiency (FXPOI). The anti-Müllerian hormone (AMH) level acts as a useful marker of ovarian follicle reserve and, thus, may serve to predict when this ovarian reserve becomes too low to sustain ovarian function. We investigated the intra-individual variation of AMH levels over time for premutation carriers compared with non-carriers.
methodsWe determined AMH levels in blood samples from 240 women ascertained through fragile X families, of which 127 were premutation carriers and 113 were non-carriers. Linear mixed models were used to assess the effect of age and premutation status on AMH levels and to determine a modeled AMH value. The stability over time of the deviation of observed AMH levels from modeled levels, referred to as standardized AMH values, was assessed through correlation coefficients of 41 longitudinal samples.
resultsAt all ages, premutation carriers exhibited lower AMH levels. For all women, AMH was found to decrease by 10% per year. The added effect of having a premutation decreased AMH levels by 54%. The deviation of an individual's AMH level from the modeled value showed a reasonable intra-individual correlation. The Pearson correlation coefficient of two samples taken at different ages was 0.36 (P = 0.05) for non-carriers and 0.69 (P = 0.01) for carriers.
conclusionsWe developed a unique standardized AMH value, taking FMR1 premutation status and the subject's age into account, which appears to be stable over time and may serve as a predictor for FXPOI after further longitudinal assessment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.