ArticleEarly human development2011
Association of antenatal steroid use with cord blood immune biomarkers in preterm births.
Article in Early human development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Cytokine patterns in very low birth weight infants under different cord clamping strategies: preliminary EXPLAIN trial data.BMC pediatrics · 2026Trial
- Trial
- Prematurity, Neonatal Complications, and the Development of Childhood Hypertension.JAMA network open · 2025Article
- Serum cytokine profiles at near term-equivalent age and their association with neurodevelopmental outcomes in preterm infants: an exploratory study.Frontiers in pediatrics · 2025Article
- The Role of TGF-β during Pregnancy and Pregnancy Complications.International journal of molecular sciences · 2023Review
- Longitudinal Trajectory and Early Life Determinant of Childhood Adipokines: Findings From a Racially Diverse Birth Cohort.The Journal of clinical endocrinology and metabolism · 2023Article
- Early-life determinants of childhood plasma insulin levels: implications for primordial prevention of diabetes.Pediatric research · 2023Article
- Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC).Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Glucocorticosteroids Effects on Brain Development in the Preterm Infant: A Role for Microglia?Current neuropharmacology · 2021Review
- The Effects of Antenatal Steroid Treatment on Preterm Infants' Early Laboratory Analysis.Sisli Etfal Hastanesi tip bulteni · 2020Article
- Dichotomous development of the gut microbiome in preterm infants.Microbiome · 2018Article
- Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity.Seminars in immunopathology · 2016Review
- Prenatal Dexamethasone and Postnatal High-Fat Diet Decrease Interferon Gamma Production through an Age-Dependent Histone Modification in Male Sprague-Dawley Rats.International journal of molecular sciences · 2016Article
- Regulatory Cytokine Expression and Preterm Birth: Case-Control Study Nested in a Cohort.PloS one · 2016Article
- Article
- Beyond Single Cutoffs: Gestational and Postnatal Age-Specific Interpretation of Neonatal Laboratory Markers.Pediatrics international : official journal of the Japan Pediatric SocietyReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesTo evaluate the effect of maternal administration of antenatal steroids (ANS) on cord blood cytokine levels at birth in preterm infants.
methodsCord blood cytokine concentrations were measured for pro-inflammatory cytokines (IL-1β, IL-6, and IL-8); anti-inflammatory cytokines (IL-4, IL-10 and TGF-β); and neurotrophic cytokines (BDNF, NT-3, and NT-4) in two hundred preterm infants. Data were analyzed using multivariable linear regression to model the independent and joint effects of ANS and inflammation on mean log cord blood cytokine concentrations adjusted for gestational age and Apgar scores.
resultsExposure to ANS had no significant effect on the cord blood concentrations of cytokines measured in this study. All three pro-inflammatory cytokine levels and levels of IL-10 were significantly increased and cord blood levels of TGF-β and NT-3 were significantly decreased in infants with placental inflammation.
conclusionAlthough exposure to ANS did not have any significant effect on cord blood levels of cytokines, there was a trend toward the attenuation of inflammatory response and higher levels of neurotrophic cytokines in infants born to mothers with placental inflammation and exposure to ANS compared to infants born to mothers with placental inflammation and no ANS exposure.
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Registered trials
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