ArticleThe EMBO journal1990
T-cell specific rearrangement of T-cell receptor beta transgenes in mice.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo.Molecular and cellular biology · 2008Article
- Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.Molecular and cellular biology · 2000Article
- Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.The Journal of experimental medicine · 1999Article
- Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.The Journal of experimental medicine · 1997Article
- In vitro generation of lymphoid precursors from embryonic stem cells.The EMBO journal · 1994Article
- Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.The Journal of experimental medicine · 1994Article
- A novel POU domain protein which binds to the T-cell receptor beta enhancer.Molecular and cellular biology · 1993Article
- A dominant-negative transgene defines a role for p56lck in thymopoiesis.The EMBO journal · 1993Article
- p70 lupus autoantigen binds the enhancer of the T-cell receptor beta-chain gene.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.Molecular and cellular biology · 1993Article
- Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.The EMBO journal · 1992Article
- Analysis of the immune system with transgenic mice: T cell development.Experientia · 1991Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study rearrangement of T cell receptor (TCR) genes, transgenic mice were generated with a TCR beta minilocus in germline configuration, containing three V beta, two D beta, fourteen J beta and two C beta gene segments and the TCR beta enhancer. Using the polymerase chain reaction as an analytical tool both partial DJ as well as complete VDJ rearrangements were seen, indicating that the minilocus contained all sequence elements required for rearrangment. Rearrangements of minilocus gene segments were restricted to T cells in the thymus and the periphery and did not occur in B cells. V beta 8.3 and V beta 5 sequences encoded by the minilocus were expressed on the surface of peripheral T cells at high frequencies. Transgenic mice with TCR minilocus genes will be a useful system to identify DNA sequence elements required for regulation of rearrangement in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.