ReviewAutoimmunity reviews2011
Immunosenescence and rheumatoid arthritis: does telomere shortening predict impending disease?
Review in Autoimmunity reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Association between shortened telomere length and rheumatoid arthritis : A meta-analysis.Zeitschrift fur Rheumatologie · 2018Pooled it
- Gender and telomere length: systematic review and meta-analysis.Experimental gerontology · 2014Pooled it
- Prevalence and transient impact of childhood abuse and neglect on health-related quality of life in Mexican patients with early rheumatoid arthritis.Clinical rheumatology · 2026Article
- Loss of LXRβ Drives CD4Biomedicines · 2026Article
- Late Onset Rheumatoid Arthritis.Aging and disease · 2025Review
- Measures of Adiposity and Risk of Rheumatoid Arthritis in Middle-Aged UK Women: A Prospective Cohort Study.Nutrients · 2025Article
- The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress.Biomolecules · 2025Review
- Review
- Immunosenescence of T cells: a key player in rheumatoid arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Review
- Associations of the MUC5B promoter variant with timing of interstitial lung disease and rheumatoid arthritis onset.Rheumatology (Oxford, England) · 2022Article
- Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells.Aging cell · 2021Article
- Association Between the Anti-Aging Gene Klotho and Selected Rheumatologic Autoimmune Diseases.The American journal of the medical sciences · 2021Review
- Telomere dysfunction promotes small vessel vasculitis via the LL37-NETs-dependent mechanism.Annals of translational medicine · 2020Article
- Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.Immunity & ageing : I & A · 2020Review
- Cellular aging over 13 years associated with incident antinuclear antibody positivity in the Baltimore Longitudinal Study of Aging.Journal of autoimmunity · 2019Article
- Telomere dysfunction-related serological markers and oxidative stress markers in rheumatoid arthritis patients: correlation with diseases activity.Clinical rheumatology · 2018Article
- Adverse childhood experience and rheumatic diseases.Clinical rheumatology · 2018Article
- Insulin-Like Growth Factor Binding Protein 6 in Rheumatoid Arthritis: A Possible Novel Chemotactic Factor?Frontiers in immunology · 2017Article
- Elevated risk for autoimmune disorders in iraq and afghanistan veterans with posttraumatic stress disorder.Biological psychiatry · 2015Article
- Are microparticles the missing link between thrombosis and autoimmune diseases? Involvement in selected rheumatologic diseases.Seminars in thrombosis and hemostasis · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The pathogenesis of RA, a disabling autoimmune disease, is incompletely understood. Early in the development of RA there appears to be loss of immune homeostasis and regulation, and premature immunosenescence. While identification of risk factors and understanding of the phases of RA pathogenesis are advancing, means of accurately predicting an individual's risk of developing RA are currently lacking. Telomere length has been proposed as a potential new biomarker for the development of RA that could enhance prediction of this serious disease. Studies examining telomere length in relation to RA have found that telomere erosion appears to proceed more rapidly in subjects with RA than in healthy controls, and that telomere lengths are shorter in those with the RA-risk HLA-shared epitope genes. These studies have been small, however, with retrospective or cross-sectional designs. The potential role of telomere shortening as an independent biomarker for future RA risk, perhaps strongly genetically determined by HLA-SE genes, after controlling for known risk factors such as smoking, body mass index and immunosuppressant medication use, as well as systemic inflammation, is an unanswered question.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.