Evidence map›Paper›PMID 21575699›Full record

ArticleJournal of ethnopharmacology2011

Toxicity of medicinal plants used in traditional medicine in Northern Peru.

R W Bussmann, G Malca, A Glenn, D Sharon, B Nilsen, B Parris, D Dubose, D Ruiz, J Saleda, M Martinez and 4 more

Abstract read
In one paragraph

Article in Journal of ethnopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
11.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 584 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Guayusa (Molecules (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Antitumor Potential ofMolecules (Basel, Switzerland) · 2021
    Article
  15. Article
  16. Evaluation ofFoods (Basel, Switzerland) · 2021
    Article
  17. Article
  18. Article
  19. Beneficial Role ofBiology · 2021
    Review
  20. Valorization ofFoods (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

R W BussmannWilliam L. Brown Center, Missouri Botanical Garden, P.O. Box 299, St. Louis, MO 63166-0299, USA. rainer.bussmann@mobot.org
G Malca
A Glenn
D Sharon
B Nilsen
B Parris
D Dubose
D Ruiz
J Saleda
M Martinez
L Carillo
K Walker
A Kuhlman
A Townesmith
Missouri Botanical Garden · USUniversity of California, Berkeley · USStony Brook University · US

Funding

Minority Health &Health Disparities International Research Training ProgramT37MD001442 · NIMHD · SAN DIEGO STATE UNIVERSITY · PI PLEMMONS, DENA · 2005 to 2018
$3.3M
NIMHD NIH HHS T37 MD001442
6 · The paper itself

Abstract

ethnopharmacological relevanceThe plant species reported here are traditionally used in Northern Peru for a wide range of illnesses. Most remedies are prepared as ethanol or aqueous extracts and then ingested. The aim of this study was to evaluate the potential toxicity of these extracts. MATERIALS AND

methodsThe toxicity of ethanolic and water extracts of 341 plant species was determined using a brine-shrimp assay.

resultsOverall 24% of the species in water extract and 76% of the species in alcoholic extract showed elevated toxicity levels to brine-shrimp. Although in most cases multiple extracts of the same species showed very similar toxicity values, in some cases the toxicity of different extracts of the same species varied from non-toxic to highly toxic.

conclusionsTraditional preparation methods take different toxicity levels in aqueous and ethanol extracts into account when choosing the appropriate solvent for the preparation of a remedy.

Indexed as

AnimalsArtemiaDose-Response Relationship, DrugEthanolLethal Dose 50Medicine, TraditionalPeruPlants, MedicinalRisk AssessmentSolventsToxicity TestsWaterEthanolSolventsWater

Identifiers

PMID21575699
PMCPMC3159793
OpenAlexW2067894486

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.