ArticleBiophysical journal2011
The molecular basis for antimicrobial activity of pore-forming cyclic peptides.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Antimicrobial peptides in anti-infective and immunomodulatory applications: Mechanisms, challenges, and emerging computational design.Zoological research · 2026Review
- How Cell-Penetrating Peptides Behave Differently from Pore-Forming Peptides: Structure and Stability of Induced Transmembrane Pores.Journal of the American Chemical Society · 2023Article
- No Chance to Survive:Antibiotics (Basel, Switzerland) · 2023Article
- Behind the Curtain: In Silico and In Vitro Experiments Brought to Light New Insights into the Anticryptococcal Action of Synthetic Peptides.Antibiotics (Basel, Switzerland) · 2023Article
- Chlorin e6 Phospholipid Delivery System Featuring APN/CD13 Targeting Peptides: Cell Death Pathways, Cell Localization, In Vivo Biodistribution.Pharmaceutics · 2022Article
- Structure and Formation Mechanism of Antimicrobial Peptides Temporin B- and L-Induced Tubular Membrane Protrusion.International journal of molecular sciences · 2021Article
- Antimicrobial Peptides from Plants: A cDNA-Library Based Isolation, Purification, Characterization Approach and Elucidating Their Modes of Action.International journal of molecular sciences · 2021Review
- Plant antimicrobial peptides: structures, functions, and applications.Botanical studies · 2021Review
- Development and Characterization of the Shortest Anti-Adhesion Peptide Analogue of B49Mod1.Molecules (Basel, Switzerland) · 2020Article
- Simplified Head-to-Tail Cyclic Polypeptides as Biomaterial-Associated Antimicrobials with Endotoxin Neutralizing and Anti-Inflammatory Capabilities.International journal of molecular sciences · 2019Article
- Lipid Bilayer Composition Influences the Activity of the Antimicrobial Peptide Dermcidin Channel.Biophysical journal · 2019Article
- Peptide-Lipid Interaction Sites Affect Vesicles' Responses to Antimicrobial Peptides.Biophysical journal · 2018Article
- Rational Design of Cyclic Antimicrobial Peptides Based on BPC194 and BPC198.Molecules (Basel, Switzerland) · 2017Article
- A monodisperse transmembrane α-helical peptide barrel.Nature chemistry · 2017Article
- Cyclization Improves Membrane Permeation by Antimicrobial Peptoids.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells.Scientific reports · 2015Article
- The VP4 peptide of hepatitis A virus ruptures membranes through formation of discrete pores.Journal of virology · 2014Article
- Functional truncated membrane pores.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Exploring the Energy Landscapes of Cyclic Tetrapeptides with Discrete Path Sampling.Journal of chemical theory and computation · 2013Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The mechanism of action of antimicrobial peptides is, to our knowledge, still poorly understood. To probe the biophysical characteristics that confer activity, we present here a molecular-dynamics and biophysical study of a cyclic antimicrobial peptide and its inactive linear analog. In the simulations, the cyclic peptide caused large perturbations in the bilayer and cooperatively opened a disordered toroidal pore, 1-2 nm in diameter. Electrophysiology measurements confirm discrete poration events of comparable size. We also show that lysine residues aligning parallel to each other in the cyclic but not linear peptide are crucial for function. By employing dual-color fluorescence burst analysis, we show that both peptides are able to fuse/aggregate liposomes but only the cyclic peptide is able to porate them. The results provide detailed insight on the molecular basis of activity of cyclic antimicrobial peptides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.