ArticleBiophysical journal2011
An analytical model for determining two-dimensional receptor-ligand kinetics.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Modeling and Validation of Oocyte Mechanical Behavior Using AFM Measurement and Multiphysics Simulation.Sensors (Basel, Switzerland) · 2025Article
- Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023Review
- Targeting Dysfunctional Vascular Endothelial Cells Using Immunoliposomes Under Flow Conditions.Cellular and molecular bioengineering · 2020Article
- E-selectin-mediated rolling facilitates pancreatic cancer cell adhesion to hyaluronic acid.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Mapping cell surface adhesion by rotation tracking and adhesion footprinting.Scientific reports · 2017Article
- Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues.PloS one · 2017Article
- High Throughput Label Free Measurement of Cancer Cell Adhesion Kinetics Under Hemodynamic Flow.Scientific reports · 2016Article
- A high-throughput mechanofluidic screening platform for investigating tumor cell adhesion during metastasis.Lab on a chip · 2016Article
- Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow.Oncotarget · 2015Article
- Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen).Biophysical journal · 2012Article
- Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions.American journal of physiology. Cell physiology · 2012Article
- Dissociation rate constants of human fibronectin binding to fibronectin-binding proteins on living Staphylococcus aureus isolated from clinical patients.The Journal of biological chemistry · 2012Article
- Bistability of cell adhesion in shear flow.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cell-cell adhesive interactions play a pivotal role in major pathophysiological vascular processes, such as inflammation, infection, thrombosis, and cancer metastasis, and are regulated by hemodynamic forces generated by blood flow. Cell adhesion is mediated by the binding of receptors to ligands, which are both anchored on two-dimensional (2-D) membranes of apposing cells. Biophysical assays have been developed to determine the unstressed (no-force) 2-D affinity but fail to disclose its dependence on force. Here we develop an analytical model to estimate the 2-D kinetics of diverse receptor-ligand pairs as a function of force, including antibody-antigen, vascular selectin-ligand, and bacterial adhesin-ligand interactions. The model can account for multiple bond interactions necessary to mediate adhesion and resist detachment amid high hemodynamic forces. Using this model, we provide a generalized biophysical interpretation of the counterintuitive force-induced stabilization of cell rolling observed by a select subset of receptor-ligand pairs with specific intrinsic kinetic properties. This study enables us to understand how single-molecule and multibond biophysics modulate the macroscopic cell behavior in diverse pathophysiological processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.