ArticleBiophysical journal2011
Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Analysis of developmental gene expression using smFISH andbioRxiv : the preprint server for biology · 2024Article
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- Perspective: Engineering noise in biological systems towards predictive stochastic design.APL bioengineering · 2018Article
- The free-energy cost of interaction between DNA loops.Scientific reports · 2017Article
- Multiplexed gene control reveals rapid mRNA turnover.Science advances · 2017Article
- Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.Nature communications · 2017Article
- Transcription Dynamics in Living Cells.Annual review of biophysics · 2016Review
- What's Luck Got to Do with It: Single Cells, Multiple Fates, and Biological Nondeterminism.Molecular cell · 2016Review
- Probing the effect of promoters on noise in gene expression using thousands of designed sequences.Genome research · 2014Article
- Breaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing.PloS one · 2014Article
- Direct observation of frequency modulated transcription in single cells using light activation.eLife · 2013Article
- Creating memories of transcription.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Eukaryotic transcriptional dynamics: from single molecules to cell populations.Nature reviews. Genetics · 2013Review
- Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts.BMC biology · 2013Article
- Article
- Inferring the kinetics of stochastic gene expression from single-cell RNA-sequencing data.Genome biology · 2013Article
- Genetic selection for context-dependent stochastic phenotypes: Sp1 and TATA mutations increase phenotypic noise in HIV-1 gene expression.PLoS computational biology · 2013Article
- Regulatory consequences of gene translocation in bacteria.Nucleic acids research · 2012Article
- Transcription stochasticity of complex gene regulation models.Biophysical journal · 2012Article
- What do expression dynamics tell us about the mechanism of transcription?Current opinion in genetics & development · 2011Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Gene expression noise varies with genomic position and is a driving force in the evolution of chromosome organization. Nevertheless, position effects remain poorly characterized. Here, we present a systematic analysis of chromosomal position effects by characterizing single-cell gene expression from euchromatic positions spanning the length of a eukaryotic chromosome. We demonstrate that position affects gene expression by modulating the size of transcriptional bursts, rather than their frequency, and that the histone deacetylase Sir2 plays a role in this process across the chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.