ArticleBiophysical journal2011
Strain transfer in ventricular cardiomyocytes to their transverse tubular system revealed by scanning confocal microscopy.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Restoring Atrial T-Tubules Augments Systolic Ca Upon Recovery From Heart Failure.Circulation research · 2024Article
- Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange.Circulation research · 2021Article
- The Physiology and Pathophysiology of T-Tubules in the Heart.Frontiers in physiology · 2021Review
- Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure.Scientific reports · 2019Article
- Highly variable contractile performance correlates with myocyte content in trabeculae from failing human hearts.Scientific reports · 2018Article
- Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma?Biophysical reviews · 2017Review
- Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics.Progress in biophysics and molecular biology · 2017Article
- T-tubular collagen: a new player in mechanosensing and disease?Cardiovascular research · 2017Article
- Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy.Current heart failure reports · 2017Review
- Article
- Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis.Cardiovascular research · 2016Article
- Measurement of Strain in Cardiac Myocytes at Micrometer Scale Based on Rapid Scanning Confocal Microscopy and Non-Rigid Image Registration.Annals of biomedical engineering · 2016Article
- An integrated finite element simulation of cardiomyocyte function based on triphasic theory.Frontiers in physiology · 2015Article
- Targeting cardiomyocyte Ca2+ homeostasis in heart failure.Current pharmaceutical design · 2015Review
- Emerging mechanisms of T-tubule remodelling in heart failure.Cardiovascular research · 2013Review
- Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte.European biophysics journal : EBJ · 2012Article
- Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy.Circulation research · 2012Article
- Mechanical modulation of the transverse tubular system of ventricular cardiomyocytes.Progress in biophysics and molecular biologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transverse tubular system (t-system) is a major site for signaling in mammalian ventricular cardiomyocytes including electrical signaling and excitation-contraction coupling. It consists of membrane invaginations, which are decorated with various proteins including mechanosensitive ion channels. Here, we investigated mechanical modulation of the t-system. By applying fluorescent markers, three-dimensional scanning confocal microscopy, and methods of digital image analysis, we studied isolated ventricular cardiomyocytes under different strains. We demonstrate that strain at the cellular level is transmitted to the t-system, reducing the length and volume of tubules and altering their cross-sectional shape. Our data suggest that a cellular strain of as little as 5% affects the shape of transverse tubules, which has important implications for the function of mechanosensitive ion channels found in them. Furthermore, our study supports a prior hypothesis that strain can cause fluid exchange between the t-system and extracellular space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.