ArticleBMC microbiology2011
Comparative fecal metagenomics unveils unique functional capacity of the swine gut.
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 1 of them a synthesis that pooled it.
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Who cites it
190 citing papers in PubMed, 1 synthesis or guideline pooled it, 362 citations in OpenAlex.
- How informative is the mouse for human gut microbiota research?Disease models & mechanisms · 2015Pooled it
- Postprandial serum endotoxin in healthy humans is modulated by dietary fat in a randomized, controlled, cross-over study.Lipids in health and disease · 2016Trial
- RuSpacer: a CRISPR spacer database derived from ruminant-associated prokaryotes for virome analysis.Scientific reports · 2026Article
- The developmental trajectory and maturation of the Hulunbuir sheep (Ovis aries) microbiome.Animal microbiome · 2026Article
- Microbial succession in human tissues postmortem: insights from 2bRAD-M sequencing.Microbiology spectrum · 2026Article
- Gut microbiota bridging spicy food intake and obesity: evidence from the China Multi-Ethnic Cohort (CMEC) study.BMC public health · 2025Article
- Effect of probiotic on fecal microbiome of broiler chicken reared at two different high altitude locations.3 Biotech · 2025Article
- Metagenomic Analysis Reveals the Characteristics of Cecal Microbiota in Chickens with Different Levels of Resistance During Recovery fromAnimals : an open access journal from MDPI · 2025Article
- Consequences of Domestication on Gut Microbiome: A Comparative Analysis Between Wild Boars and Domestic Pigs.Animals : an open access journal from MDPI · 2025Article
- Protease andAnimals : an open access journal from MDPI · 2025Article
- Fecal microbiota profiling in organic and conventional dairy farms differing in farm-level somatic cell counts and raw milk bacterial infections.Frontiers in veterinary science · 2025Article
- Feed efficiency and fecal microbiome of nursery pigs from parents with divergent breeding value for feed conversion ratio.Translational animal science · 2025Article
- Effects of Acute Salinity Stress on the Histological and Bacterial Community Structure and Function in Intestine ofMarine drugs · 2024Article
- Parity changed fecal microbiota of sows and its correlation with milk long-chain fatty acid profiles.Applied microbiology and biotechnology · 2024Article
- Effects of Dietary Fiber and Copper on the Performance and Gut Microbiota of Finishing Pigs.Animals : an open access journal from MDPI · 2024Article
- Alteration in the Gut Microbiota of Chickens Resistant toMicroorganisms · 2024Article
- Effects of High-Grain Diet on Performance, Ruminal Fermentation, and Rumen Microbial Flora of Lactating Holstein Dairy Cows.Animals : an open access journal from MDPI · 2024Article
- Research Note: Analysis of microbial diversity on the shell surface of eggs collected from geographically distinct farms in China.Poultry science · 2024Article
- Effects of supplemental bacteriophage on the gut microbiota and nutrient digestibility of ileal-cannulated pigs.Journal of animal science and technology · 2024Article
- Swine Gastrointestinal Microbiota and the Effects of Dietary Amino Acids on Its Composition and Metabolism.International journal of molecular sciences · 2024Review
130 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUncovering the taxonomic composition and functional capacity within the swine gut microbial consortia is of great importance to animal physiology and health as well as to food and water safety due to the presence of human pathogens in pig feces. Nonetheless, limited information on the functional diversity of the swine gut microbiome is available.
resultsAnalysis of 637, 722 pyrosequencing reads (130 megabases) generated from Yorkshire pig fecal DNA extracts was performed to help better understand the microbial diversity and largely unknown functional capacity of the swine gut microbiome. Swine fecal metagenomic sequences were annotated using both MG-RAST and JGI IMG/M-ER pipelines. Taxonomic analysis of metagenomic reads indicated that swine fecal microbiomes were dominated by Firmicutes and Bacteroidetes phyla. At a finer phylogenetic resolution, Prevotella spp. dominated the swine fecal metagenome, while some genes associated with Treponema and Anareovibrio species were found to be exclusively within the pig fecal metagenomic sequences analyzed. Functional analysis revealed that carbohydrate metabolism was the most abundant SEED subsystem, representing 13% of the swine metagenome. Genes associated with stress, virulence, cell wall and cell capsule were also abundant. Virulence factors associated with antibiotic resistance genes with highest sequence homology to genes in Bacteroidetes, Clostridia, and Methanosarcina were numerous within the gene families unique to the swine fecal metagenomes. Other abundant proteins unique to the distal swine gut shared high sequence homology to putative carbohydrate membrane transporters.
conclusionsThe results from this metagenomic survey demonstrated the presence of genes associated with resistance to antibiotics and carbohydrate metabolism suggesting that the swine gut microbiome may be shaped by husbandry practices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.