ArticleJournal of the American Chemical Society2011
An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Copper(II/III) Redox Couple Enables C─H Methylation via a Radical Mechanism Analogous to SAM Enzymes.Angewandte Chemie (International ed. in English) · 2026Article
- Iron-Sulfur Cluster Enzymes of the Methylerythritol Phosphate Pathway: IspG and IspH.Biochemistry · 2025Review
- Metalloenzymes involved in carotenoid biosynthesis in plants.Methods in enzymology · 2022Article
- An [FeJournal of the American Chemical Society · 2020Article
- A Synthetic Model of Enzymatic [FeJournal of the American Chemical Society · 2019Article
- EPR-Derived Structure of a Paramagnetic Intermediate Generated by Biotin Synthase BioB.Journal of the American Chemical Society · 2018Article
- Advanced paramagnetic resonance spectroscopies of iron-sulfur proteins: Electron nuclear double resonance (ENDOR) and electron spin echo envelope modulation (ESEEM).Biochimica et biophysica acta · 2015Review
- Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis.Angewandte Chemie (International ed. in English) · 2014Review
- Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation.Chemical science · 2014Article
- Advanced electron paramagnetic resonance on the catalytic iron-sulfur cluster bound to the CCG domain of heterodisulfide reductase and succinate: quinone reductase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2013Article
- Isoprenoid biosynthesis: ferraoxetane or allyl anion mechanism for IspH catalysis?Angewandte Chemie (International ed. in English) · 2013Article
- Methylerythritol phosphate pathway of isoprenoid biosynthesis.Annual review of biochemistry · 2013Review
- Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.Journal of the American Chemical Society · 2012Article
- A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase.Biochemistry · 2012Article
- 9-Mercaptodethiobiotin is generated as a ligand to the [2Fe-2S]+ cluster during the reaction catalyzed by biotin synthase from Escherichia coli.Journal of the American Chemical Society · 2012Article
- Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
IspG is a 4Fe-4S protein that carries out an essential reduction step in isoprenoid biosynthesis. Using electron-nuclear double resonance (ENDOR) and hyperfine sublevel correlation (HYSCORE) spectroscopies on labeled samples, we have specifically assigned the hyperfine interactions in a reaction intermediate. These results help clarify the nature of the reaction intermediate, supporting a direct interaction between the unique fourth Fe in the cluster and C2 and O3 of the ligand.
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