ArticleHepatology (Baltimore, Md.)2011
Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration.
Article in Hepatology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 79 citations in OpenAlex.
- Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression.Genes & diseases · 2024Article
- Exploring the roles of non-coding RNAs in liver regeneration.Non-coding RNA research · 2024Review
- Role of the Hippo pathway in liver regeneration and repair: recent advances.Inflammation and regeneration · 2022Review
- Involvement of microRNAs and their potential diagnostic, therapeutic, and prognostic role in hepatocellular carcinoma.Journal of clinical laboratory analysis · 2022Review
- Diverse MicroRNAs-mRNA networks regulate the priming phase of mouse liver regeneration and of direct hyperplasia.Cell proliferation · 2022Article
- Hsa-miR-637 inhibits human hepatocyte proliferation by targeting Med1-interacting proteins.Liver research (Beijing, China) · 2021Article
- Regeneration linked miRNA modify tumor phenotype and can enforce multi-lineage growth arrest in vivo.Scientific reports · 2021Article
- Molecular and Functional Roles of MicroRNAs in the Progression of Hepatocellular Carcinoma-A Review.International journal of molecular sciences · 2020Review
- Brg1 regulates murine liver regeneration by targeting miR-187-5p dependent on Hippo signalling pathway.Journal of cellular and molecular medicine · 2020Article
- Partial hepatectomy‑induced upregulation of SNHG12 promotes hepatocyte proliferation and liver regeneration.Molecular medicine reports · 2020Article
- MiR-27a/b Regulates Liver Regeneration by Posttranscriptional Modification of Tmub1.Digestive diseases and sciences · 2018Article
- Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis.Journal of clinical and translational research · 2018Article
- Profiling the circulating miRnome reveals a temporal regulation of the bone injury response.Theranostics · 2018Article
- Modeling bias and variation in the stochastic processes of small RNA sequencing.Nucleic acids research · 2017Article
- Dicer-dependent production of microRNA221 in hepatocytes inhibits p27 and is required for liver regeneration in mice.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration.International journal of molecular medicine · 2017Article
- MicroRNAs in the Evaluation and Potential Treatment of Liver Diseases.Journal of clinical medicine · 2016Review
- Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis ofFrontiers in microbiology · 2016Article
- MicroRNA biogenesis and cellular proliferation.Translational research : the journal of laboratory and clinical medicine · 2015Article
- Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation.World journal of gastroenterology · 2015Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
unlabelledThe liver is one of the few organs that have the capacity to regenerate in response to injury. We carried out genomewide microRNA (miRNA) microarray studies during liver regeneration in rats after 70% partial hepatectomy (PH) at early and mid time points to more thoroughly understand their role. At 3, 12, and 18 hours post-PH ∼40% of the miRNAs tested were up-regulated. Conversely, at 24 hours post-PH, ∼70% of miRNAs were down-regulated. Furthermore, we established that the genomewide down-regulation of miRNA expression at 24 hours was also correlated with decreased expression of genes, such as Rnasen, Dgcr8, Dicer, Tarbp2, and Prkra, associated with miRNA biogenesis. To determine whether a potential negative feedback loop between miRNAs and their regulatory genes exists, 11 candidate miRNAs predicted to target the above-mentioned genes were examined and found to be up-regulated at 3 hours post-PH. Using reporter and functional assays, we determined that expression of these miRNA-processing genes could be regulated by a subset of miRNAs and that some miRNAs could target multiple miRNA biogenesis genes simultaneously. We also demonstrated that overexpression of these miRNAs inhibited cell proliferation and modulated cell cycle in both Huh-7 human hepatoma cells and primary rat hepatocytes. From these observations, we postulated that selective up-regulation of miRNAs in the early phase after PH was involved in the priming and commitment to liver regeneration, whereas the subsequent genomewide down-regulation of miRNAs was required for efficient recovery of liver cell mass.
conclusionOur data suggest that miRNA changes are regulated by negative feedback loops between miRNAs and their regulatory genes that may play an important role in the steady-state regulation of liver regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.