ArticleDiabetologia2011
Altered gap junctional communication and renal haemodynamics in Zucker fatty rat model of type 2 diabetes.
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Connexin 43 and Pannexin 1 in Renal Cell Populations in Diabetic Kidney Disease.International journal of molecular sciences · 2026Article
- Article
- Rodent models to study type 1 and type 2 diabetes induced human diabetic nephropathy.Molecular biology reports · 2023Review
- Intrarenal Mechanisms of Sodium-Glucose Cotransporter-2 Inhibitors on Tubuloglomerular Feedback and Natriuresis.Endocrinology and metabolism (Seoul, Korea) · 2023Review
- Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.Frontiers in pharmacology · 2022Article
- Glomerular hyperfiltration with hyperglycemia in the spontaneously diabetic Torii (SDT) fatty rat, an obese type 2 diabetic model.Physiological research · 2021Article
- PUFAs supplementation affects the renal expression of pannexin 1 and connexins in diabetic kidney of rats.Histochemistry and cell biology · 2020Article
- Novel Targets for Therapy of Renal Fibrosis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Review
- Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes.Acta physiologica (Oxford, England) · 2019Article
- Differential gene expression profiling of the sciatic nerve in type 1 and type 2 diabetic mice.Biomedical reports · 2018Article
- Connexin channel and its role in diabetic retinopathy.Progress in retinal and eye research · 2017Review
- How the kidney hyperfiltrates in diabetes: From molecules to hemodynamics.World journal of diabetes · 2015Review
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Mind the gap: connexins and cell-cell communication in the diabetic kidney.Diabetologia · 2015Review
- Article
- Fibroblast growth factor 23 enhances renal klotho abundance.Pflugers Archiv : European journal of physiology · 2013Article
- Connexin43 mediates NF-κB signalling activation induced by high glucose in GMCs: involvement of c-Src.Cell communication and signaling : CCS · 2013Article
- Distribution and functional relevance of connexins in renin-producing cells.Pflugers Archiv : European journal of physiology · 2013Review
- Increased susceptibility to hypertensive renal disease in streptozotocin-treated diabetic rats is not modulated by salt intake.Diabetologia · 2012Article
- TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transition.Diabetologia · 2012Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisWe examined the link between altered gap junctional communication and renal haemodynamic abnormalities in diabetes in studies performed on Zucker lean (ZL) and the Zucker diabetic fatty (ZDF) rat model of type 2 diabetes.
methodsThe abundance of connexin (Cx) 37, 40 and 43 was assessed by western blot and immunohistochemistry. Renal haemodynamics was characterised with GAP peptides, which are Cx mimetics, to inhibit gap junctions as a probe in both strains.
resultsZDF rats exhibited higher plasma glucose, 8-epi-prostaglandin F2α excretion, renal plasma flow and GFR than ZL rats. In ZDF rat kidney phosphorylation of Cx43 was enhanced compared with that in ZL rats. Immunohistochemical study revealed that the density of abundance of Cx37 in renin-secreting cells was significantly reduced in ZDF rats. Although renal autoregulation was markedly impaired in ZDF rats, it was preserved in ZL rats. GAP27 for Cx37,43 and for Cx40 impaired renal autoregulation in ZL rats, but failed to induce further alterations in renal autoregulation in ZDF rats. CONCLUSIONS/
interpretationOur findings indicate that ZDF rats have glomerular hyperfiltration with impaired autoregulation. They also demonstrate enhanced phosphorylation of Cxs and reduced production of Cxs in ZDF rat kidney, especially of Cx37 in renin-secreting cells. Finally, our data suggest that an impairment of gap junctional communication in juxtaglomerular apparatus plays a role in altered renal autoregulation in diabetes.
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