ArticlePharmaceutical research2011
Effect of sugar molecules on the viscosity of high concentration monoclonal antibody solutions.
Article in Pharmaceutical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 111 citations in OpenAlex.
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- Droplet-Based Microfluidic Tool to Quantify Viscosity of Concentrating Protein Solutions.Pharmaceutical research · 2021Article
- Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design.PloS one · 2020Article
- Studying Excipient Modulated Physical Stability and Viscosity of Monoclonal Antibody Formulations Using Small-Angle Scattering.Molecular pharmaceutics · 2019Article
- Viscosity Control of Protein Solution by Small Solutes: A Review.Current protein & peptide science · 2018Review
- Charge Shielding Prevents Aggregation of Supercharged GFP Variants at High Protein Concentration.Molecular pharmaceutics · 2017Article
- Multi-criteria manufacturability indices for ranking high-concentration monoclonal antibody formulations.Biotechnology and bioengineering · 2017Article
- Contrasting the Influence of Cationic Amino Acids on the Viscosity and Stability of a Highly Concentrated Monoclonal Antibody.Pharmaceutical research · 2017Article
- Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months.Nature communications · 2016Article
- Parallel temperature-dependent microrheological measurements in a microfluidic chip.Biomicrofluidics · 2016Article
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- Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the effect of sugar molecules on solution viscosity at high protein concentrations.
methodsA high throughput dynamic light scattering method was used to measure the viscosity of monoclonal antibody solutions. The effects of protein concentration, type of sugar molecule (trehalose, sucrose, sorbitol, glucose, fructose, xylose and galactose), temperature and ionic strength were evaluated. Differential scanning fluorimetry was used to reveal the effect of the same sugars on protein stability and to provide insight into the mechanism by which sugars increase viscosity.
resultsThe addition of all seven types of sugar molecules studied result in a significant increase in viscosity of high concentration monoclonal antibody solutions. Similar effects of sugars were observed in the two mAbs examined; viscosity could be reduced by increasing the ionic strength or temperature. The effect by sugars was enhanced at higher protein concentrations.
conclusionsDisaccharides have a greater effect on the solution viscosity at high protein concentrations compared to monosaccharides. The effect may be explained by commonly accepted mechanisms of interactions between sugar and protein molecules in solution.
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Registered trials
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