ArticleDigestive diseases and sciences2011
Hepatic osteodystrophy is common in patients with noncholestatic liver disease.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Osteoporosis and bone fractures in alcoholic liver disease: a meta-analysis.World journal of gastroenterology · 2015Pooled it
- Vitamin D status and viral response to therapy in hepatitis C infected children.World journal of gastroenterology · 2015Trial
- Advancements in the pathogenesis of hepatic osteodystrophy and the potential therapeutic of mesenchymal stromal cells.Stem cell research & therapy · 2023Review
- Vitamin D status & bone health in patients with liver cirrhosis.The Indian journal of medical research · 2023Article
- Prevalence and Trends in Low Bone Density, Osteopenia and Osteoporosis in U.S. Adults With Non-Alcoholic Fatty Liver Disease, 2005-2014.Frontiers in endocrinology · 2021Article
- Common musculoskeletal disorders in chronic liver disease patients.Joint diseases and related surgery · 2021Article
- Hepatic osteodystrophy and fracture risk prediction using FRAX tool in Indian patients with cirrhosis.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Hepatic Osteodystrophy-Molecular Mechanisms Proposed to Favor Its Development.International journal of molecular sciences · 2019Review
- Vitamin D and Chronic Diseases.Aging and disease · 2017Review
- Vitamin D status in patients with cirrhosis of the liver and their relatives-A case control study from North India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Article
- Study of Hepatic Osteodystrophy in Patients with Chronic Liver Disease.Journal of clinical and diagnostic research : JCDR · 2016Article
- Crucial Role of Vitamin D in the Musculoskeletal System.Nutrients · 2016Review
- Liver Transplantation for Alcohol-Related Liver Disease.Journal of clinical and experimental hepatology · 2016Review
- Lower relapse rates with good post-transplant outcome in alcoholic liver disease: Experience from a living donor liver transplant center.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Article
- Prospective study of profile of hepatic osteodystrophy in patients with non-choleastatic liver cirrhosis and impact of bisphosphonate supplementation.United European gastroenterology journal · 2016Article
- Nonalcoholic fatty liver disease and decreased bone mineral density: is there a link?Journal of endocrinological investigation · 2015Review
- Vitamin D deficiency in chronic liver disease.World journal of hepatology · 2014Review
- Increased bone mineral density in patients with non-alcoholic steatohepatitis.World journal of hepatology · 2013Article
- Spontaneus bilateral pedicle fracture 30 years after Harrington Instrumentation for idiopathic scoliosis: a case report.Journal of medical case reports · 2012Article
- Classical and emerging roles of vitamin D in hepatitis C virus infection.Seminars in liver disease · 2011Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with cirrhosis are more prone to develop metabolic bone disease. Scanty literature data are available on osteodystrophy in patients from India with noncholestatic liver diseases.
methodsPatients diagnosed with cirrhosis were prospectively evaluated for bone mineral density (BMD) as measured by dual-energy X-ray absorptiometry at the femoral neck, lumbar spine, and left forearm (distal radius). Correlation of BMD with age, sex, etiology of cirrhosis, Child's class, serum bilirubin, alkaline phosphatase (ALP), albumin, calcium, phosphate, 25-hydroxyvitamin D (25(OH)D), and parathyroid hormone (PTH) was studied.
resultsThe study group comprised 115 cirrhotic patients (107 males and 8 females). Etiology of cirrhosis was alcohol in 67 (58.2%) and viral in 48 (41.7%). Hepatitis B was diagnosed in 29 (25.2%) and hepatitis C in 19 (16.5%). Mean age was 49 (± 5.5) years. Prevalence of osteodystrophy was significantly higher in males than in females; 97.1% and 75% respectively (P = .038). Both alcoholic and viral groups had similar baseline characteristics except albumin levels. Child's class was B in 72 patients and C in 43. Low BMD was present in 97% of patients with alcoholic cirrhosis and 93.7% with viral cirrhosis (P > .05). Low BMD was present at the femoral neck in 80.8% of patients, lumbar spine in 77.3%, and forearm in 59.9%. PTH correlated negatively with BMD.
conclusionOsteodystrophy is common in alcoholic and viral cirrhosis patients.
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