ArticlePloS one2011
Olfactory and visuospatial learning and memory performance in two strains of Alzheimer's disease model mice--a longitudinal study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Differential roles of human tau isoforms in the modulation of inflammation and development of neuropathology.Neurobiology of disease · 2025Article
- Targeting of phosphorylated tau at threonine 181 by a Qβ virus-like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse.Frontiers in aging neuroscience · 2023Article
- Exploratory Research on Key Technology of Human-Computer Interactive 2.5-Minute Fast Digital Early Warning for Mild Cognitive Impairment.Computational intelligence and neuroscience · 2022Article
- Effects of altered tau expression on dentate granule cell excitability in mice.Experimental neurology · 2021Article
- Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy.Neurobiology of disease · 2021Article
- Age- and Nicotine-Associated Gene Expression Changes in the Hippocampus of APP/PS1 Mice.Journal of molecular neuroscience : MN · 2019Article
- Insulin-Like Growth Factor-1 Alleviates Expression of AβJournal of molecular neuroscience : MN · 2018Article
- Stable olfactory sensory neuron in vivo physiology during normal aging.Neurobiology of aging · 2018Article
- NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy.Behavioural brain research · 2018Article
- Tolfenamic Acid: A Modifier of the Tau Protein and its Role in Cognition and Tauopathy.Current Alzheimer research · 2018Article
- Article
- Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers.Journal of neuropathology and experimental neurology · 2016Article
- Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease.Acta neuropathologica · 2015Article
- Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice.Scientific reports · 2015Article
- Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease.Experimental neurology · 2015Article
- Olfactory Dysfunction in the Elderly: Basic Circuitry and Alterations with Normal Aging and Alzheimer's Disease.Current geriatrics reports · 2014Article
- Cortical odor processing in health and disease.Progress in brain research · 2014Review
- Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease.PloS one · 2014Article
- Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.PloS one · 2014Article
Corrections and comments
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5 authors.
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Abstract
Using a longitudinal study design, two strains of Alzheimer's disease (AD) model mice, one expressing β-amyloid plaques and one expressing Tau protein-associated neurofibrillary tangles were assessed for olfactory and visuospatial learning and memory and their performance compared to that of age-matched controls. No significant difference between AD and control mice was found in the initial set of olfactory tasks performed at 6 months of age whereas both strains of AD mice performed significantly poorer than the controls in visuospatial learning at this age. Subsequent tests performed on the same individual animals at 7, 8, 9, 11, 13, 15, and 18 months of age also failed to find systematic differences in olfactory performance between AD and control mice. In contrast, the AD mice performed consistently poorer than the controls in visuospatial re-learning tests performed at these ages. With most olfactory tasks, both AD and control mice displayed a marked decrease in performance between testing at 15 and 18 months of age. These results show that the two strains of AD model mice do not display an olfactory impairment in a time course consistent with human AD, but are impaired in visuospatial capabilities. The marked age-related changes observed with the olfactory tasks in both AD and control mice suggest that the observed lack of an AD-related olfactory impairment is not due to an insensitivity of the tests employed. Rather, they suggest that the olfactory system of the two AD mouse model strains may be surprisingly robust against AD-typical neuropathologies.
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