ArticlePloS one2011
Direction-selective circuitry in rat retina develops independently of GABAergic, cholinergic and action potential activity.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Activity-dependent development of synaptic circuits mediates direction selectivity in an axis-specific manner.Cell reports · 2025Article
- How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders.Frontiers in molecular neuroscience · 2022Review
- Development of Functional Properties in the Early Visual System: New Appreciations of the Roles of Lateral Geniculate Nucleus.Current topics in behavioral neurosciences · 2022Review
- Retinal waves prime visual motion detection by simulating future optic flow.Science (New York, N.Y.) · 2021Article
- BDNF improves axon transportation and rescues visual function in a rodent model of acute elevation of intraocular pressure.Science China. Life sciences · 2020Article
- GABA release selectively regulates synapse development at distinct inputs on direction-selective retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Stimulus-dependent engagement of neural mechanisms for reliable motion detection in the mouse retina.Journal of neurophysiology · 2018Review
- Cholinergic excitation complements glutamate in coding visual information in retinal ganglion cells.The Journal of physiology · 2018Article
- Stimulus-dependent recruitment of lateral inhibition underlies retinal direction selectivity.eLife · 2016Article
- Development of synaptic connectivity in the retinal direction selective circuit.Current opinion in neurobiology · 2016Review
- Role for Visual Experience in the Development of Direction-Selective Circuits.Current biology : CB · 2016Article
- CaV3.2 KO mice have altered retinal waves but normal direction selectivity.Visual neuroscience · 2015Article
- Subtype-dependent postnatal development of direction- and orientation-selective retinal ganglion cells in mice.Journal of neurophysiology · 2014Article
- Functional architecture of the retina: development and disease.Progress in retinal and eye research · 2014Review
- Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling.eLife · 2014Article
- Genetic dissection of retinal inputs to brainstem nuclei controlling image stabilization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The distribution of the preferred directions of the ON-OFF direction selective ganglion cells in the rabbit retina requires refinement after eye opening.Physiological reports · 2013Article
- Direction selectivity in the retina: symmetry and asymmetry in structure and function.Nature reviews. Neuroscience · 2012Review
- Organization and development of direction-selective circuits in the retina.Trends in neurosciences · 2011Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ON-OFF direction selective ganglion cells (DSGCs) in the mammalian retina code image motion by responding much more strongly to movement in one direction. They do so by receiving inhibitory inputs selectively from a particular sector of processes of the overlapping starburst amacrine cells, a type of retinal interneuron. The mechanisms of establishment and regulation of this selective connection are unknown. Here, we report that in the rat retina, the morphology, physiology of the ON-OFF DSGCs and the circuitry for coding motion directions develop normally with pharmacological blockade of GABAergic, cholinergic activity and/or action potentials for over two weeks from birth. With recent results demonstrating light independent formation of the retinal DS circuitry, our results strongly suggest the formation of the circuitry, i.e., the connections between the second and third order neurons in the visual system, can be genetically programmed, although emergence of direction selectivity in the visual cortex appears to require visual experience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.