ArticlePloS one2011
Schistosome infection intensity is inversely related to auto-reactive antibody levels.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Placental gene expression and antibody levels of mother-neonate pairs reveal an enhanced risk for inflammation in a helminth endemic country.Scientific reports · 2019Trial
- Herpes simplex virus type 2 in sub-Saharan Africa and the potential impact of helminth immune modulation.Frontiers in cellular and infection microbiology · 2024Review
- Regulatory T-cells in helminth infection: induction, function and therapeutic potential.Immunology · 2020Review
- Cross-Domain and Viral Interactions in the Microbiome.Microbiology and molecular biology reviews : MMBR · 2019Review
- Aberrant plasma MMP and TIMP dynamics in Schistosoma - Immune reconstitution inflammatory syndrome (IRIS).PLoS neglected tropical diseases · 2018Article
- Helminths in the gastrointestinal tract as modulators of immunity and pathology.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Microbes and Viruses Are Bugging the Gut in Celiac Disease. Are They Friends or Foes?Frontiers in microbiology · 2017Review
- Regulation of the host immune system by helminth parasites.The Journal of allergy and clinical immunology · 2016Review
- Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase.Infection and immunity · 2015Article
- Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children.PLoS neglected tropical diseases · 2015Article
- Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation.Frontiers in immunology · 2015Article
- Helminths in the hygiene hypothesis: sooner or later?Clinical and experimental immunology · 2014Review
- Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.PLoS neglected tropical diseases · 2014Article
- Antigen Mimicry between Infectious Agents and Self or Environmental Antigens May Lead to Long-Term Regulation of Inflammation.Frontiers in immunology · 2013Review
- Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis.The Journal of infectious diseases · 2013Article
- Sources of heterogeneity in human monocyte subsets.Immunology letters · 2013Article
- Helminth infections and host immune regulation.Clinical microbiology reviews · 2012Review
- Schistosoma haematobium infection levels determine the effect of praziquantel treatment on anti-schistosome and anti-mite antibodies.Parasite immunology · 2012Article
- Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children.PLoS neglected tropical diseases · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
In animal experimental models, parasitic helminth infections can protect the host from auto-immune diseases. We conducted a population-scale human study investigating the relationship between helminth parasitism and auto-reactive antibodies and the subsequent effect of anti-helminthic treatment on this relationship. Levels of antinuclear antibodies (ANA) and plasma IL-10 were measured by enzyme linked immunosorbent assay in 613 Zimbabweans (aged 2-86 years) naturally exposed to the blood fluke Schistosoma haematobium. ANA levels were related to schistosome infection intensity and systemic IL-10 levels. All participants were offered treatment with the anti-helminthic drug praziquantel and 102 treated schoolchildren (5-16 years) were followed up 6 months post-antihelminthic treatment. ANA levels were inversely associated with current infection intensity but were independent of host age, sex and HIV status. Furthermore, after allowing for the confounding effects of schistosome infection intensity, ANA levels were inversely associated with systemic levels of IL-10. ANA levels increased significantly 6 months after anti-helminthic treatment. Our study shows that ANA levels are attenuated in helminth-infected humans and that anti-helminthic treatment of helminth-infected people can significantly increase ANA levels. The implications of these findings are relevant for understanding both the aetiology of immune disorders mediated by auto-reactive antibodies and in predicting the long-term consequences of large-scale schistosomiasis control programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.