ArticlePloS one2011
Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Genome-wide association susceptibility loci for cluster headache support a role for inflammation in the pathophysiology.The journal of headache and pain · 2026Pooled it
- Association of vitamin D receptor BsmI gene polymorphism with risk of osteoporosis: a meta-analysis of 41 studies.Molecular biology reports · 2013Pooled it
- Two genetic variants in the HIBCH and FTCDNL1 genes are associated with susceptibility to developmental dysplasia of the hips among the Han Chinese population of Southwest China.Journal of orthopaedic surgery and research · 2024Article
- Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications.Bone research · 2021Review
- Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis.Disease markers · 2020Article
- Analyzing Genome-Wide Association Study Dataset Highlights Immune Pathways in Lip Bone Mineral Density.Frontiers in genetics · 2020Article
- Transforming growth factor-β in stem cells and tissue homeostasis.Bone research · 2018Article
- A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women.Bone reports · 2016Article
- The Effect of Some Polymorphisms in Vitamin D Receptor Gene in Menopausal Women with Osteoporosis.Journal of clinical and diagnostic research : JCDR · 2016Article
- The genetics of bone mass and susceptibility to bone diseases.Nature reviews. Rheumatology · 2016Review
- Article
- Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Further delineation of the SATB2 phenotype.European journal of human genetics : EJHG · 2014Article
- Genetics of ossification of the posterior longitudinal ligament of the spine: a mini review.Journal of bone metabolism · 2014Review
- Genome-wide approaches for identifying genetic risk factors for osteoporosis.Genome medicine · 2013Review
- A short history of the genome-wide association study: where we were and where we are going.Genomics & informatics · 2012Article
- Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.The Journal of clinical endocrinology and metabolism · 2012Review
- Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women.PloS one · 2012Article
- Osteoporosis genetics: year 2011 in review.BoneKEy reports · 2012Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is a common disease characterized by low bone mass, decreased bone quality and increased predisposition to fracture. Genetic factors have been implicated in its etiology; however, the specific genes related to susceptibility to osteoporosis are not entirely known. To detect susceptibility genes for osteoporosis, we conducted a genome-wide association study in Japanese using ∼270,000 SNPs in 1,747 subjects (190 cases and 1,557 controls) followed by multiple levels of replication of the association using a total of ∼5,000 subjects (2,092 cases and 3,114 controls). Through these staged association studies followed by resequencing and linkage disequilibrium mapping, we identified a single nucleotide polymorphism (SNP), rs7605378 associated with osteoporosis. (combined P = 1.51×10(-8), odds ratio = 1.25). This SNP is in a previously unknown gene on chromosome 2q33.1, FONG. FONG is predicted to encode a 147 amino-acid protein with a formiminotransferase domain in its N-terminal (FTCD_N domain) and is ubiquitously expressed in various tissues including bone. Our findings would give a new insight into osteoporosis etiology and pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.