ArticlePloS one2011
The Ras/MAPK pathway is required for generation of iNKT cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data.Seminars in immunology · 2022Review
- Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation.Frontiers in oncology · 2022Review
- Development of αβ T Cells with Innate Functions.Advances in experimental medicine and biology · 2022Article
- Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice.European journal of immunology · 2020Article
- TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway.Cellular & molecular immunology · 2020Article
- PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision.Cellular & molecular immunology · 2019Article
- Differential Control ofFrontiers in immunology · 2019Article
- TCR signal strength controls thymic differentiation of iNKT cell subsets.Nature communications · 2018Article
- Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates.Frontiers in immunology · 2018Review
- A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.Nature communications · 2017Article
- Development of invariant natural killer T cells.Current opinion in immunology · 2016Review
- Diacylglycerol Kinases in T Cell Tolerance and Effector Function.Frontiers in cell and developmental biology · 2016Review
- Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- mTOR and its tight regulation for iNKT cell development and effector function.Molecular immunology · 2015Review
- The transcriptional programs of iNKT cells.Seminars in immunology · 2015Review
- Article
- The differential roles of mTOR, ERK, and JNK pathways in invariant natural killer T-cell function and survival.Inflammation · 2014Article
- ID'ing innate and innate-like lymphoid cells.Immunological reviews · 2014Review
- Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Increased level of E protein activity during invariant NKT development promotes differentiation of invariant NKT2 and invariant NKT17 subsets.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
iNKT cells derive from CD4(+)CD8(+) DP thymocytes, and are selected by thymocyte-thymocyte interactions through signals from their invariant Vα14-Jα18 TCR and from the costimulatory molecules SLAMF1 and SLAMF6. Genetic studies have demonstrated the contribution of different signaling pathways to this process. Surprisingly, current models imply that the Ras/MAPK pathway, one of the critical mediators of conventional αβ T cell positive selection, is not necessary for iNKT cell development. Using mice defective at different levels of this pathway our results refute this paradigm, and demonstrate that Ras, and its downstream effectors Egr-1 and Egr-2 are required for positive selection of iNKT cells. Interestingly our results also show that there are differences in the contributions of several of these molecules to the development of iNKT and conventional αβ T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.