SynthesisPloS one2011
Relationship between TNF-<alpha> gene promoter polymorphisms and outcomes of hepatitis B virus infections: a meta-analysis.
Synthesis in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Association between TNF α gene polymorphisms and the risk of duodenal ulcer: a meta-analysis.PloS one · 2013Pooled it
- Impact of TNF-α (- 308G>A and - 857 C>T) promoter variants on susceptibility to chronic hepatitis B virus infection in a cohort of Mauritanian patients: pilot study.BMC microbiology · 2026Article
- Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants.International journal of hepatology · 2022Article
- TNF-α polymorphisms affect persistence and progression of HBV infection.Molecular genetics & genomic medicine · 2019Article
- Association ofJournal of advanced research · 2019Article
- Correlations of TNF-α gene promoter polymorphisms with the risk of thymoma-associated myasthenia gravis in a northern Chinese Han population.Cancer gene therapy · 2017Article
- Association of TNF-α Gene Polymorphisms with Production of Protein and Susceptibility to Chronic Hepatitis B Infection in the South East Iranian Population.Hepatitis monthly · 2016Article
- Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma.World journal of hepatology · 2016Review
- Polymorphisms in the feline TNFA and CD209 genes are associated with the outcome of feline coronavirus infection.Veterinary research · 2014Article
- Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children.BMC research notes · 2014Article
- Associations of IFN-γ rs2430561 T/A, IL28B rs12979860 C/T and ERα rs2077647 T/C polymorphisms with outcomes of hepatitis B virus infection: a meta-analysis.Journal of biomedical research · 2014Article
- Relationship between cytokine gene polymorphisms and chronic hepatitis B virus infection.World journal of gastroenterology · 2014Review
- Association of the interleukin-12 polymorphic variants with the development of antibodies to surface antigen of hepatitis B virus in hemodialysis patients in response to vaccination or infection.Molecular biology reports · 2013Article
- Vitamin D and Tumor Necrosis Factor-Alpha Receptor Gene Polymorphisms in Various Hepatitis B Clinical Conditions in Turkey.Gastroenterology research · 2013Article
- TNF-α -863 polymorphisms and the risk of hepatocellular carcinoma.Experimental and therapeutic medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clearance of hepatitis B virus (HBV) is a complex process which may be influenced by many factors including polymorphisms in the tumor necrosis factor <alpha> (TNF-<alpha>) gene promoter. However, previous reports regarding the relationship between polymorphisms in the TNF-<alpha> promoter and HBV clearance have been inconsistent. Therefore, we performed a meta-analysis on a large population to address this inconsistency.
methodsA meta-analysis was performed to examine the association between TNF-<alpha> promoter polymorphisms (-1031T/C, -863C/A, -857C/T, -308G/A and-238G/A) and chronic hepatitis B infection. Odds ratio (OR) and its 95 % confidence interval (CI) were used.
resultsTwelve studies were chosen in our meta-analysis, involving 2,754 chronic HBV infection cases and 1,630 HBV clearance cases. The data showed that TNF-<alpha>-863 CC genotype was significantly associated with HBV clearance (-863 CC vs. AA: OR, 0.64; 95% CI, [0.42, 0.97]; p = 0.04) while patients carrying -308 GG genotype had a significantly increased risk of HBV persistence compared with those with GA or AA genotype (GG vs. GA+AA: OR, 1.35; 95% CI, [1.08, 1.70]; p = 0.01). For the other polymorphisms, no association with HBV infection outcome was found.
conclusionsThe data showed that polymorphisms -863 A and -308 G in the TNF-<alpha> gene promoter region might be risk factors for HBV persistence. Furthermore, ethnicity might play an important role in HBV infection outcome, leading to conflicting results. More studies on individuals from various ethnic groups will be necessary to determine the role of TNF-<alpha> promoter polymorphisms in the outcome of HBV infection.
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