Evidence map›Paper›PMID 21572551›Full record

ArticleCardiac electrophysiology clinics2011

Deciphering Arrhythmia Mechanisms - Tools of the Trade.

Guy Salama, Fadi G Akar

Open access · greenAbstract read
In one paragraph

Article in Cardiac electrophysiology clinics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Guy SalamaUniversity of Pittsburgh, The Cardiovascular Institute, Pittsburgh, PA, 15261.
Fadi G Akar
Icahn School of Medicine at Mount Sinai · USUniversity of Pittsburgh · US

Funding

Effects of K+ Accumulation/Depletion in the HeartR01HL093074 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SALAMA, GUY · 2010 to 2013
$1.9M
Factors that Initiate Arrhythmias in lung QT SyndromeR01HL057929 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SALAMA, GUY · 1998 to 2006
$1.5M
MECHANISMS OF REPOLARIZATION-INDUCED ARRHYTHMIASR01HL059614 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SALAMA, GUY · 1999 to 2002
$760k
Integrative Investigation of Mitochondrial DysfunctionR21HL097108 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKAR, FADI GABRIEL · 2011 to 2012
$466k
NHLBI NIH HHS R01 HL057929NHLBI NIH HHS R01 HL059614NHLBI NIH HHS R01 HL093074NHLBI NIH HHS R21 HL097108
6 · The paper itself

Abstract

Pathophysiological remodeling of cardiac function occurs at multiple levels, spanning the spectrum from molecular and sub-cellular changes to those occurring at the organ-system levels. Of key importance to arrhythmias are changes in electrophysiological and calcium handling properties at the tissue level. In this review, we discuss how high-resolution optical action potential and calcium transient imaging has advanced our understanding of basic arrhythmia mechanisms associated with multiple cardiovascular disorders, including the long QT syndrome, heart failure, and ischemia-reperfusion injury. We focus on the role of repolarization gradients (section 1) and calcium mediated triggers (section 2) in the initiation and maintenance of complex arrhythmias in these settings.

Identifiers

PMID21572551
PMCPMC3093299
OpenAlexW1994502097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.