ArticleNature structural & molecular biology2011
Global analysis of parental imprinting in human parthenogenetic induced pluripotent stem cells.
Article in Nature structural & molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Pluripotent stem cell-specific imprinted genes identified using human uniparental-induced pluripotent stem cells.Journal of advanced research · 2026Article
- Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci.Cell proliferation · 2026Article
- Differentiation of uniparental human embryonic stem cells into granulosa cells reveals a paternal contribution to gonadal development.Stem cell reports · 2023Article
- Generation of human androgenetic induced pluripotent stem cells.Scientific reports · 2020Article
- Higher expression of cation transport regulator-like protein 1 (CHAC1) predicts of poor outcomes in uveal melanoma (UM) patients.International ophthalmology · 2019Article
- Epigenetic aberrations in human pluripotent stem cells.The EMBO journal · 2019Review
- Alteration of Genomic Imprinting Status of Human Parthenogenetic Induced Pluripotent Stem Cells during Neural Lineage Differentiation.International journal of stem cells · 2019Article
- How Does Reprogramming to Pluripotency Affect Genomic Imprinting?Frontiers in cell and developmental biology · 2019Review
- Novel imprinted single CpG sites found by global DNA methylation analysis in human parthenogenetic induced pluripotent stem cells.Epigenetics · 2018Article
- Identification and propagation of haploid human pluripotent stem cells.Nature protocols · 2016Article
- Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions.Scientific reports · 2016Article
- Pluripotent stem cells in disease modelling and drug discovery.Nature reviews. Molecular cell biology · 2016Review
- Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.Stem cell reports · 2015Article
- The noncoding RNA IPW regulates the imprinted DLK1-DIO3 locus in an induced pluripotent stem cell model of Prader-Willi syndrome.Nature genetics · 2014Article
- Virtual karyotyping of pluripotent stem cells on the basis of their global gene expression profiles.Nature protocols · 2013Article
- Global indiscriminate methylation in cell-specific gene promoters following reprogramming into human induced pluripotent stem cells.Stem cell reports · 2013Article
- Identification of novel imprinted differentially methylated regions by global analysis of human-parthenogenetic-induced pluripotent stem cells.Stem cell reports · 2013Article
- Immunogenicity of in vitro maintained and matured populations: potential barriers to engraftment of human pluripotent stem cell derivatives.Methods in molecular biology (Clifton, N.J.) · 2013Review
- Accumulation of instability in serial differentiation and reprogramming of parthenogenetic human cells.Human molecular genetics · 2012Article
- Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients.British journal of cancer · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the role of parental imprinting in human embryogenesis, we generated parthenogenetic human induced pluripotent stem cells (iPSCs) with a homozygote diploid karyotype. Global gene expression and DNA methylation analyses of the parthenogenetic cells enabled the identification of the entire repertoire of paternally expressed genes. We thus demonstrated that the gene U5D, encoding a variant of the U5 small RNA component of the spliceosome, is an imprinted gene. Introduction of the U5D gene into parthenogenetic cells partially corrected their molecular phenotype. Our analysis also uncovered multiple miRNAs existing as imprinted clustered transcripts, whose putative targets we then studied further. Examination of the consequences of parthenogenesis on human development identified marked effects on the differentiation of extraembryonic trophectoderm and embryonic liver and muscle tissues. This analysis suggests that distinct regulatory imprinted small RNAs and their targets have substantial roles in human development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.