Trial reportAIDS (London, England)2011
Association of recent HIV infection and in-utero HIV-1 transmission.
Trial report in AIDS (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02445989 (Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity
Who cites it
19 citing papers in PubMed.
- Pregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancy.Journal of acquired immune deficiency syndromes (1999) · 2018Trial
- Acceptability of and Adherence to an Antiretroviral-Based Vaginal Microbicide among Pregnant Women in the United States.AIDS and behavior · 2018Trial
- Maternal HIV Infection and Antiretroviral Therapy in Pregnancy: Implications for Vertical Transmission, Fetal Safety, and Long-Term Infant Outcomes.Pathogens (Basel, Switzerland) · 2025Review
- Incident HIV acquisition among pregnant women in Botswana: findings from the Tsepamo birth outcomes surveillance study.Journal of the International AIDS Society · 2023Article
- The Ontogeny and Function of Placental Macrophages.Frontiers in immunology · 2021Review
- Cost-effectiveness analysis of infant feeding modalities for virally suppressed mothers in Canada living with HIV.Medicine · 2019Article
- HIV in pregnancy: Identification of intrapartum and perinatal HIV exposures.Paediatrics & child health · 2019Review
- Article
- Strategies for screening cord blood for a public cord blood bank in high HIV prevalence regions.Global health, epidemiology and genomics · 2018Review
- Performing Drug Safety Research During Pregnancy and Lactation: Biomedical HIV Prevention Research as a Template.Journal of women's health (2002) · 2016Article
- Paediatric HIV infection: the potential for cure.Nature reviews. Immunology · 2016Review
- Detection of Acute and Early HIV-1 Infections in an HIV Hyper-Endemic Area with Limited Resources.PloS one · 2016Article
- Are infants unique in their ability to be "functionally cured" of HIV-1?Current HIV/AIDS reports · 2014Article
- Immunology of pediatric HIV infection.Immunological reviews · 2013Review
- Article
- Article
- Progress, challenges, and new opportunities for the prevention of mother-to-child transmission of HIV under the US President's Emergency Plan for AIDS Relief.Journal of acquired immune deficiency syndromes (1999) · 2012Review
- Pregnant women's access to PMTCT and ART services in South Africa and implications for universal antiretroviral treatment.PloS one · 2011Article
- A randomized safety and pharmacokinetic trial of daily tenofovir 1% gel in term and near-term pregnancy.Journal of the International AIDS SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectiveWe previously developed a multiassay algorithm (MAA) to identify recent HIV infection that includes the BED-capture enzyme immunoassay, an avidity assay based on the Genetic Systems HIV-1/HIV-2 + O enzyme immunoassay, CD4 cell count, and HIV viral load. We used this MAA to evaluate the association between recent maternal HIV infection and in-utero transmission of HIV.
methodsPlasma samples were collected at delivery from 2561 HIV-infected women in the postexposure prophylaxis of infants-Malawi trial. The MAA described above was used to identify women with recent HIV infection. Logistic regression models assessed association between recent HIV infection and in-utero HIV transmission (defined as a positive infant HIV DNA test at birth).
resultsSeventy-three women were identified as recently infected using the MAA. Those women were younger and had lower parity than women who were identified as not recently infected using the MAA (P < 0.0001 for age and parity). The frequency of in-utero HIV transmission was 17.8% among women identified as recently infected, compared with 6.7% among women identified as not recently infected (13/73 vs. 166/2488, P = 0.001). In a multivariate model, three factors were independently associated with in-utero HIV transmission: recent infection [adjusted odds ratio (AOR): 2.49, 95% confidence interval (CI): 1.30-4.78, P = 0.006], log(10) HIV viral load at delivery (AOR: 2.01, 95% CI: 1.60-2.51, P < 0.0001), and younger age (per 10 year increase, AOR: 0.66, 95% CI: 0.43-0.93, P = 0.02).
conclusionResults obtained using a MAA suggest that recent maternal HIV acquisition is strongly associated with in-utero HIV transmission, independent of HIV viral load at delivery.
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