ArticleJournal of medical genetics2011
MEIS1 and BTBD9: genetic association with restless leg syndrome in end stage renal disease.
Article in Journal of medical genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- [Frequent neurological diseases associated with the restless legs syndrome].Der Nervenarzt · 2018Pooled it
- Genome-wide association study of restless legs syndrome in end-stage renal disease.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Restless legs syndrome in chronic renal failure patients on dialysis.African health sciences · 2023Article
- Article
- Unraveling the Mysteries of Restless Leg Syndrome.Cureus · 2020Review
- Homeobox gene Meis1 modulates cardiovascular regeneration.Seminars in cell & developmental biology · 2020Review
- Rotigotine suppresses sleep-related muscle activity augmented by injection of dialysis patients' sera in a mouse model of restless legs syndrome.Scientific reports · 2019Article
- PTPRD: neurobiology, genetics, and initial pharmacology of a pleiotropic contributor to brain phenotypes.Annals of the New York Academy of Sciences · 2019Review
- Reporting Quality of Randomized Controlled Trials in Restless Legs Syndrome Based on the CONSORT Statement.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Article
- Restless legs syndrome/Willis-Ekbom disease prevalence in beta thalassemia patients.Sleep & breathing = Schlaf & Atmung · 2018Article
- Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome.Frontiers in behavioral neuroscience · 2018Article
- Lack of Association Between Shape and Volume of Subcortical Brain Structures and Restless Legs Syndrome.Frontiers in neurology · 2018Article
- Sleep Disorders, Restless Legs Syndrome, and Uremic Pruritus: Diagnosis and Treatment of Common Symptoms in Dialysis Patients.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Review
- Genetic associations of periodic limb movements of sleep in the elderly for the MrOS sleep study.Sleep medicine · 2015Article
- MEIS1, a Promising Candidate Gene, Is Not Associated with the Core Symptoms of Antipsychotic-Induced Restless Legs Syndrome in Korean Schizophrenia Patients.Psychiatry investigation · 2015Article
- Article
- Polymorphisms of interleukin-1 Beta and interleukin-17Alpha genes are associated with restless legs syndrome.Biological research for nursing · 2014Article
- Treatment of restless legs syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Restless legs syndrome and its associated risk factors in Parkinson's disease.Parkinson's disease · 2013Article
- Restless legs syndrome in dialysis patients: a comparison between hemodialysis and continuous ambulatory peritoneal dialysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Article
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRestless legs syndrome (RLS) is a sleep related movement disorder that occurs both in an idiopathic form and in symptomatic varieties. RLS is a frequent and distressing comorbidity in end stage renal disease (ESRD). For idiopathic RLS (iRLS), genetic risk factors have been identified, but their role in RLS in ESRD has not been investigated yet. Therefore, a case-control association study of these variants in ESRD patients was performed.
methodsThe study genotyped 10 iRLS associated variants at four loci encompassing the genes MEIS1, BTBD9, MAP2K5/SKOR1, and PTPRD, in two independent case-control samples from Germany and Greece using multiplex PCR and MALDI-TOF (matrix assisted laser desorption/ionisation time-of-flight) mass spectrometry. Statistical analysis was performed as logistic regression with age and gender as covariates. For the combined analysis a Cochran-Mantel-Haenszel test was applied.
resultsThe study included 200 RLS-positive and 443 RLS-negative ESRD patients in the German sample, and 141 and 393 patients, respectively, in the Greek sample. In the German sample, variants in MEIS1 and BTBD9 were associated with RLS in ESRD (P(nom)≤0.004, ORs 1.52 and 1.55), whereas, in the Greek sample, there was a trend for association to MAP2K5/SKOR1 and BTBD9 (P(nom)≤0.08, ORs 1.41 and 1.33). In the combined analysis including all samples, BTBD9 was associated after correction for multiple testing (P(corrected)=0.0013, OR 1.47).
conclusionsThis is the first demonstration of a genetic influence on RLS in ESRD patients with BTBD9 being significantly associated. The extent of the genetic predisposition could vary between different subgroups of RLS in ESRD.
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