ArticleToxicologic pathology2011
Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer.
Article in Toxicologic pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Article
- Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin.Environmental health perspectives · 2020Article
- Mechanistic roles of microRNAs in hepatocarcinogenesis: A study of thioacetamide with multiple doses and time-points of rats.Scientific reports · 2017Article
- Commemorating Toxicology at the National Institute of Environmental Health Sciences on the Occasion of Its 50th Anniversary.Environmental health perspectives · 2016Article
- Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease.Cancer medicine · 2016Article
- A multiple testing procedure for multi-dimensional pairwise comparisons with application to gene expression studies.BMC bioinformatics · 2016Article
- Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.Toxicologic pathology · 2015Article
- Mixed directional false discovery rate control in multiple pairwise comparisons using weighted p-values.Biometrical journal. Biometrische Zeitschrift · 2015Article
- Dysfunctional mitochondrial bioenergetics and the pathogenesis of hepatic disorders.Frontiers in cell and developmental biology · 2015Review
- Dose-dependent incidence of hepatic tumors in adult mice following perinatal exposure to bisphenol A.Environmental health perspectives · 2014Article
- Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.Cancer letters · 2014Review
- Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways.Toxicologic pathology · 2013Article
- Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury.Toxicologic pathology · 2013Article
- Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Article
- Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer.Toxicologic pathology · 2012Article
- Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs).The Journal of biological chemistry · 2012Article
- Comparative histomorphological review of rat and human hepatocellular proliferative lesions.Journal of toxicologic pathology · 2012Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Hepatocellular carcinoma (HCC) is an important cause of morbidity and mortality worldwide. Although the risk factors of human HCC are well known, the molecular pathogenesis of this disease is complex, and in general, treatment options remain poor. The use of rodent models to study human cancer has been extensively pursued, both through genetically engineered rodents and rodent models used in carcinogenicity and toxicology studies. In particular, the B6C3F1 mouse used in the National Toxicology Program (NTP) two-year bioassay has been used to evaluate the carcinogenic effects of environmental and occupational chemicals, and other compounds. The high incidence of spontaneous HCC in the B6C3F1 mouse has challenged its use as a model for chemically induced HCC in terms of relevance to the human disease. Using global gene expression profiling, we identify the dysregulation of several mediators similarly altered in human HCC, including re-expression of fetal oncogenes, upregulation of protooncogenes, downregulation of tumor suppressor genes, and abnormal expression of cell cycle mediators, growth factors, apoptosis regulators, and angiogenesis and extracellular matrix remodeling factors. Although major differences in etiology and pathogenesis remain between human and mouse HCC, there are important similarities in global gene expression and molecular pathways dysregulated in mouse and human HCC. These data provide further support for the use of this model in hazard identification of compounds with potential human carcinogenicity risk, and may help in better understanding the mechanisms of tumorigenesis resulting from chemical exposure in the NTP two-year carcinogenicity bioassay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.