ArticleCerebral cortex (New York, N.Y. : 1991)2012
Early folding patterns and asymmetries of the normal human brain detected from in utero MRI.
Article in Cerebral cortex (New York, N.Y. : 1991), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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120 citing papers in PubMed.
- Influences of Brain Size, Sex, and Sex Chromosome Complement on the Architecture of Human Cortical Folding.Cerebral cortex (New York, N.Y. : 1991) · 2017Trial
- Cerebral Lateralization is Protective in the Very Prematurely Born.Cerebral cortex (New York, N.Y. : 1991) · 2015Trial
- New human-specific brain landmark: the depth asymmetry of superior temporal sulcus.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- The superior temporal asymmetrical pit remains asymmetric in autism spectrum disorder.bioRxiv : the preprint server for biology · 2026Article
- Fundamentals of fetal brain MRI: indications, technique, and normal anatomy.Pediatric radiology · 2026Review
- Prenatal Volume in the Bilateral Superior Temporal Gyrus Associates With Children's Expressive Vocabulary at 24-36 Months.Developmental science · 2026Article
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Linking changes in sulcal morphometry to cognitive development from childhood to adolescence.Communications biology · 2026Article
- MRI-based spectral analysis of fetal brain gyrification in typical development and in lissencephaly and polymicrogyria.Scientific reports · 2026Article
- Relationship between atypical language lateralization and cognition in pediatric patients with drug-resistant focal epilepsy: role of working memory.Frontiers in neurology · 2026Article
- Before hormones: early sex-specific mechanisms shaping nervous system development, function, and postnatal disease susceptibility.Frontiers in behavioral neuroscience · 2026Review
- Development of the social perception pathway across the third trimester of gestation and perinatal transition.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Long-term effects of preterm birth on cortical folding trajectories in early childhood.Brain communications · 2026Article
- Evaluating reliability of automated quantitative brain morphometry from fetal T2-weighted MRI.Frontiers in neuroscience · 2026Article
- The auditory environment drives superior temporal sulcus depth in the neonatal period.Brain structure & function · 2025Article
- A computational model of radial scaffolds in the human fetal brain based on MRI.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Typical development of the human fetal subplate: regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.bioRxiv : the preprint server for biology · 2025Article
- Prenatal brain connectivity and postnatal language: how familial risk and prenatal speech exposure shape early language skills.Scientific reports · 2025Article
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Longitudinal magnetic resonance imaging reveals differences in cortical expansion in fetuses with congenital heart defects.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
60 more citing papers are in PubMed but not listed here.
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Abstract
Early cortical folding and the emergence of structural brain asymmetries have been previously analyzed by neuropathology as well as qualitative analysis of magnetic resonance imaging (MRI) of fetuses and preterm neonates. In this study, we present a dedicated image analysis framework and its application for the detection of folding patterns during the critical period for the formation of many primary sulci (20-28 gestational weeks). Using structural information from in utero MRI, we perform morphometric analysis of cortical plate surface development and modeling of early folding in the normal fetal brain. First, we identify regions of the fetal brain surface that undergo significant folding changes during this developmental period and provide precise temporal staging of these changes for each region of interest. Then, we highlight the emergence of interhemispheric structural asymmetries that may be related to future functional specialization of cortical areas. Our findings complement previous descriptions of early sulcogenesis based on neuropathology and qualitative evaluation of 2D in utero MRI by accurate spatial and temporal mapping of the emergence of individual sulci as well as structural brain asymmetries. The study provides the missing starting point for their developmental trajectories and extends our understanding of normal cortical folding.
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