ArticleInvestigative ophthalmology & visual science2011
Regional and temporal differences in gene expression of LH(BETA)T(AG) retinoblastoma tumors.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Evidence of Tumour Microenvironment and Stromal Cellular Components in Retinoblastoma.Ocular oncology and pathology · 2019Article
- Identification of pathogenic genes of pterygium based on the Gene Expression Omnibus database.International journal of ophthalmology · 2019Article
- Genetic causes of hypomagnesemia, a clinical overview.Pediatric nephrology (Berlin, Germany) · 2017Review
- Targeting Notch signaling as a novel therapy for retinoblastoma.Oncotarget · 2016Article
- Optical coherence tomography enables imaging of tumor initiation in the TAg-RB mouse model of retinoblastoma.Molecular vision · 2015Article
- Intravitreal and subconjunctival melphalan for retinoblastoma in transgenic mice.Journal of ophthalmology · 2014Article
- Retinoblastoma treatment: impact of the glycolytic inhibitor 2-deoxy-d-glucose on molecular genomics expression in LH(BETA)T(AG) retinal tumors.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- The TAg-RB murine retinoblastoma cell of origin has immunohistochemical features of differentiated Muller glia with progenitor properties.Investigative ophthalmology & visual science · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study was to evaluate by microarray the hypothesis that LH(BETA)T(AG) retinoblastoma tumors exhibit regional and temporal variations in gene expression.
methodsLH(BETA)T(AG) mice aged 12, 16, and 20 weeks were euthanatized (n = 9). Specimens were taken from five tumor areas (apex, anterior lateral, center, base, and posterior lateral). Samples were hybridized to gene microarrays. The data were preprocessed and analyzed, and genes with a P < 0.01, according to the ANOVA models, and a log(2)-fold change >2.5 were considered to be differentially expressed. Differentially expressed genes were analyzed for overlap with known networks by using pathway analysis tools.
resultsThere were significant temporal (P < 10(-8)) and regional differences in gene expression for LH(BETA)T(AG) retinoblastoma tumors. At P < 0.01 and log(2)-fold change >2.5, there were significant changes in gene expression of 190 genes apically, 84 genes anterolaterally, 126 genes posteriorly, 56 genes centrally, and 134 genes at the base. Differentially expressed genes overlapped with known networks, with significant involvement in regulation of cellular proliferation and growth, response to oxygen levels and hypoxia, regulation of cellular processes, cellular signaling cascades, and angiogenesis.
conclusionsThere are significant temporal and regional variations in the LH(BETA)T(AG) retinoblastoma model. Differentially expressed genes overlap with key pathways that may play pivotal roles in murine retinoblastoma development. These findings suggest the mechanisms involved in tumor growth and progression in murine retinoblastoma tumors and identify pathways for analysis at a functional level, to determine significance in human retinoblastoma. Microarray analysis of LH(BETA)T(AG) retinal tumors showed significant regional and temporal variations in gene expression, including dysregulation of genes involved in hypoxic responses and angiogenesis.
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