ArticleProceedings of the National Academy of Sciences of the United States of America2011
Integrin adhesion drives the emergent polarization of active cytoskeletal stresses to pattern cell delamination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
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- Two types of critical cell density for mechanical elimination of abnormal cell clusters from epithelial tissue.PLoS computational biology · 2022Article
- Crosstalk between basal extracellular matrix adhesion and building of apical architecture during morphogenesis.Biology open · 2021Review
- Symmetry Breaking and Epithelial Cell Extrusion.Cells · 2020Review
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- Atomic Force Microscopy-Based Nanoscopy of Chondrogenically Differentiating Human Adipose-Derived Stem Cells: Nanostructure and Integrin β1 Expression.Nanoscale research letters · 2018Article
- Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease.Annual review of cell and developmental biology · 2018Review
- Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging.Scientific reports · 2018Article
- Theoretical Analysis of Stress Distribution and Cell Polarization Surrounding a Model Wound.Biophysical journal · 2018Article
- Actomyosin pulsation and flows in an active elastomer with turnover and network remodeling.Nature communications · 2017Article
- Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.Annual review of cell and developmental biology · 2017Review
- Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis.PLoS computational biology · 2017Article
- Advancing Edge Speeds of Epithelial Monolayers Depend on Their Initial Confining Geometry.PloS one · 2016Article
- Forces driving epithelial wound healing.Nature physics · 2014Article
- Local, cell-nonautonomous feedback regulation of myosin dynamics patterns transitions in cell behavior: a role for tension and geometry?Molecular biology of the cell · 2013Article
- Bringing balance by force: live cell extrusion controls epithelial cell numbers.Trends in cell biology · 2013Review
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
- Cell crawling mediates collective cell migration to close undamaged epithelial gaps.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue patterning relies on cellular reorganization through the interplay between signaling pathways and mechanical stresses. Their integration and spatiotemporal coordination remain poorly understood. Here we investigate the mechanisms driving the dynamics of cell delamination, diversely deployed to extrude dead cells or specify distinct cell fates. We show that a local mechanical stimulus (subcellular laser perturbation) releases cellular prestress and triggers cell delamination in the amnioserosa during Drosophila dorsal closure, which, like spontaneous delamination, results in the rearrangement of nearest neighbors around the delaminating cell into a rosette. We demonstrate that a sequence of "emergent cytoskeletal polarities" in the nearest neighbors (directed myosin flows, lamellipodial growth, polarized actomyosin collars, microtubule asters), triggered by the mechanical stimulus and dependent on integrin adhesion, generate active stresses that drive delamination. We interpret these patterns in the language of active gels as asters formed by active force dipoles involving surface and body stresses generated by each cell and liken delamination to mechanical yielding that ensues when these stresses exceed a threshold. We suggest that differential contributions of adhesion, cytoskeletal, and external stresses must underlie differences in spatial pattern.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.