ArticleProceedings of the National Academy of Sciences of the United States of America2011
Imaging the electromechanical activity of the heart in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 83 citations in OpenAlex.
- Assessing the atrial electromechanical coupling during atrial focal tachycardia, flutter, and fibrillation using electromechanical wave imaging in humans.Computers in biology and medicine · 2015Trial
- Electromechanical wave imaging vs electrocardiographic imaging: a direct comparison of non-invasive ventricular activation mapping modalities.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension.Journal of translational medicine · 2025Article
- Physiological simulation of atrial-ventricular mechanical interaction in male rats during the cardiac cycle.Pflugers Archiv : European journal of physiology · 2025Article
- Long-term atrial arrhythmia characterization and treatment efficacy evaluation using non-invasive echocardiography-based electromechanical cycle length mapping: a case series.European heart journal. Case reports · 2024Article
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- Electromechanical Cycle Length Mapping for atrial arrhythmia detection and cardioversion success assessment.Computers in biology and medicine · 2023Article
- Simultaneous Widefield Voltage and Dye-Free Optical Mapping Quantifies Electromechanical Waves in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.ACS photonics · 2023Article
- A New Electromechanical Wave Imaging Dispersion Metric for the Characterization of Ventricular Activation in Different Cardiac Resynchronization Therapy Pacing Schemes.IEEE transactions on bio-medical engineering · 2023Article
- Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond.European heart journal · 2022Review
- Ultrafast four-dimensional imaging of cardiac mechanical wave propagation with sparse optoacoustic sensing.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Electromechanical Wave Imaging With Machine Learning for Automated Isochrone Generation.IEEE transactions on medical imaging · 2021Article
- Cardiac Resynchronization Therapy Response Assessment with Electromechanical Activation Mapping within 24 Hours of Device Implantation: A Pilot Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021Article
- From Anatomy to Functional and Molecular Biomarker Imaging and Therapy: Ultrasound Is Safe, Ultrafast, Portable, and Inexpensive.Investigative radiology · 2020Review
- Optical mapping of electromechanics in intact organs.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- 4D cardiac electromechanical activation imaging.Computers in biology and medicine · 2019Article
- Pulse Wave Imaging in Carotid Artery Stenosis Human Patients in Vivo.Ultrasound in medicine & biology · 2019Article
- Non-invasive Characterization of Focal Arrhythmia with Electromechanical Wave Imaging in Vivo.Ultrasound in medicine & biology · 2018Article
- Article
- Recent technological advancements in cardiac ultrasound imaging.Ultrasonics · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cardiac conduction abnormalities remain a major cause of death and disability worldwide. However, as of today, there is no standard clinical imaging modality that can noninvasively provide maps of the electrical activation. In this paper, electromechanical wave imaging (EWI), a novel ultrasound-based imaging method, is shown to be capable of mapping the electromechanics of all four cardiac chambers at high temporal and spatial resolutions and a precision previously unobtainable in a full cardiac view in both animals and humans. The transient deformations resulting from the electrical activation of the myocardium were mapped in 2D and combined in 3D biplane ventricular views. EWI maps were acquired during five distinct conduction configurations and were found to be closely correlated to the electrical activation sequences. EWI in humans was shown to be feasible and capable of depicting the normal electromechanical activation sequence of both atria and ventricles. This validation of EWI as a direct, noninvasive, and highly translational approach underlines its potential to serve as a unique imaging tool for the early detection, diagnosis, and treatment monitoring of arrhythmias through ultrasound-based mapping of the transmural electromechanical activation sequence reliably at the point of care, and in real time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.