Evidence map›Paper›PMID 21571570›Full record

SynthesisParkinsonism & related disorders2011

Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.

Daan C Velseboer, Rob J de Haan, Wouter Wieling, David S Goldstein, Rob M A de Bie

3 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Parkinsonism & related disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 168 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03775096 phase2active not recruitingnot on this mapstarted 2019, after this paper: background citation

The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease

TypeinterventionalSponsorMichele Tagliati, MDRan2019 to 2026Enrolled15ConditionsREM Sleep Behavior Disorder, Pre-motor Parkinson Disease, Symptomatic Parkinson DiseaseArmsCarvedilol
NCT04510922 phase4completednot on this mapstarted 2019, after this paper: background citation

Technology-Based Objective Measures for Gait and Postural Assessment in Parkinson Disease Patients With Orthostatic Hypotension: Feasibility and Effect-Size Finding Study

TypeinterventionalSponsorAlberto Espay, MD, MScRan2019 to 2020Enrolled9ConditionsOrthostatic Hypotension, Idiopathic Parkinson DiseaseArmsDroxidopa 100 MG [Northera]
NCT05109364 phase2active not recruitingnot on this mapstarted 2022, after this paper: background citation

The Effect of alpha1- Adrenergic Receptor Antagonist Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease: A Follow up Study

TypeinterventionalSponsorCedars-Sinai Medical CenterRan2022 to 2026Enrolled15ConditionsSymptomatic Parkinson Disease, REM Sleep Behavior Disorder, Pre-motor Parkinson's DiseaseArmsTerazosin therapy
3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Effects of levodopa/carbidopa intestinal gel infusion on autonomic symptoms in advanced Parkinson's disease: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Pooled it
  2. Guideline
  3. Pooled it
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  8. Association of orthostatic hypotension with Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Pooled it
  9. Pooled it
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  11. Trial
  12. Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Trial
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  20. Small Strokes, Big Impact: Excessive Mortality After Acute Ischemic Stroke in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article

108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daan C VelseboerDepartment of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
Rob J de Haan
Wouter Wieling
David S Goldstein
Rob M A de Bie

Funding

Biomarkers of Parkinson Disease and Related DisordersZIANS003034 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2009 to 2025
$22.8M
Mechanisms of Parkinson Disease and Related DisordersZIANS003033 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2009 to 2022
$8.2M
Biomarkers of Parkinson Disease and Related DisordersZ01NS003034 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2007 to 2008
$3.9M
Treatment of Catecholaminergic NeurodegenerationZIANS003125 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2011 to 2022
$3.2M
Mechanisms of Parkinson Disease and Related DisordersZ01NS003033 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2007 to 2008
$966k
Intramural NIH HHS Z01 NS003033Intramural NIH HHS Z01 NS003034Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

backgroundAlthough orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature.

methodsFrom PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis.

resultsWe found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses.

conclusionsThe estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed.

Indexed as

HumansHypotension, OrthostaticParkinson DiseasePrevalence

Identifiers

PMID21571570
PMCPMC5199613

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.