ArticleThe Journal of surgical research2012
Hydrogen sulfide modulates contractile function in rat jejunum.
Article in The Journal of surgical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Role of hydrogen sulfide in health and disease.MedComm · 2024Review
- Effects of hydrogen sulfide on relaxation responses in the lower esophageal sphincter in rabbits: the potential role of potassium channels.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Hydrogen Sulfide Ameliorates Lung Ischemia-Reperfusion Injury Through SIRT1 Signaling Pathway in Type 2 Diabetic Rats.Frontiers in physiology · 2020Article
- Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide.Pharmacology research & perspectives · 2017Article
- Augmentation of cGMP/PKG pathway and colonic motility by hydrogen sulfide.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Hydrogen sulphide as a signalling molecule regulating physiopathological processes in gastrointestinal motility.British journal of pharmacology · 2017Review
- Hydrogen Sulfide in Physiology and Diseases of the Digestive Tract.Microorganisms · 2015Review
- Hydrogen sulfide-induced enhancement of gastric fundus smooth muscle tone is mediated by voltage-dependent potassium and calcium channels in mice.World journal of gastroenterology · 2015Article
- Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells.American journal of physiology. Cell physiology · 2015Article
- H2 S modulates duodenal motility in male rats via activating TRPV1 and K(ATP) channels.British journal of pharmacology · 2014Article
- Hydrogen sulfide signaling in the gastrointestinal tract.Antioxidants & redox signaling · 2014Review
- Hydrogen sulfide deficiency and diabetic renal remodeling: role of matrix metalloproteinase-9.American journal of physiology. Endocrinology and metabolism · 2013Article
- Effects of hydrogen sulphide on motility patterns in the rat colon.British journal of pharmacology · 2013Article
- Actions of hydrogen sulfide and ATP-sensitive potassium channels on colonic hypermotility in a rat model of chronic stress.PloS one · 2013Article
- Role of hydrogen sulfide as a gasotransmitter in modulating contractile activity of circular muscle of rat jejunum.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEffects of hydrogen sulfide (H(2)S), a third gasotransmitter of the gut, are not well understood. The aim of this study was to determine effects/mechanisms of H(2)S action on contractile function in rat jejunal muscle.
methodsTransmural strips of longitudinal muscle were evaluated. Response to sodium hydrosulfide (NaHS, H(2)S donor; 10(-5)-10(-3)M) was studied on spontaneous contractile activity and after precontraction (bethanechol, 3 × 10(-6)M). Atropine, propranolol, phentolamine, tetrodotoxin, capsaicin, L-N(G)-nitro arginine (L-NNA), and glibenclamide were used to determine mechanisms. L-cysteine (10(-4)-10(-2)M; substrate for H(2)S production) and aminooxyacetic acid and DL-propargylglycine (inhibitors of enzymes generating H(2)S endogenously) were used to study endogenous production. Aminooxyacetic acid, DL-propargylglycine, L-NNA, and vasoactive intestinal polypeptide (VIP) antagonist [D-p-Cl-Phe(6),Leu(17)]-VIP were used to study H(2)S release during electrical field stimulation (EFS) and interaction with VIP and nitric oxide. Immunohistofluorescence of jejunal whole mounts was performed for endogenous H(2)S-producing enzymes.
resultsCystathionine-β-synthase and cystathionine-γ-lyase were expressed only in myenteric plexus. NaHS suppressed spontaneous and stimulated contractile activity (P < 0.01). Glibenclamide prevented some suppression by NaHS (P = 0.01) of stimulated contractile activity but did not prevent suppression of spontaneous contractile activity. Other drugs had no effect on spontaneous contractile activity but increased inhibitory effects of NaHS on spontaneous and stimulated contractile activity (P < 0.05). L-cysteine had no effects on contractile activity. Inhibitors altered basal and stimulated activity suggesting endogenous release of H(2)S.
conclusionsH(2)S presumably suppresses contractile activity in jejunum by direct effects on smooth muscle. Mechanism(s) of inhibition remains unclear, because blocking known neurotransmitters enhanced H(2)S-induced suppression, while blocking adenosine triphosphate (ATP)-sensitive K(+)-channels did not block H(2)S-induced inhibition.
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