ArticleBiological psychiatry2011
Preclinical validation of a novel cocaine exposure therapy for relapse prevention.
Article in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence.Psychopharmacology · 2012Trial
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Animal Models of the Behavioral Symptoms of Substance Use Disorders.Cold Spring Harbor perspectives in medicine · 2021Review
- Molecular and circuit mechanisms regulating cocaine memory.Cellular and molecular life sciences : CMLS · 2020Review
- Activation of mGluR2/3 following stress hormone exposure restores sensitivity to alcohol in rats.Alcohol (Fayetteville, N.Y.) · 2015Article
- A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking.Nature communications · 2015Article
- Role of cues and contexts on drug-seeking behaviour.British journal of pharmacology · 2014Review
- Reinstatement in a cocaine versus food choice situation: reversal of preference between drug and non-drug rewards.Addiction biology · 2014Article
- Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- The effects of varied extinction procedures on contingent cue-induced reinstatement in Sprague-Dawley rats.Psychopharmacology · 2013Article
- Conditioned contribution of peripheral cocaine actions to cocaine reward and cocaine-seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Learning to forget: manipulating extinction and reconsolidation processes to treat addiction.Psychopharmacology · 2013Review
- Neural Changes Developed during the Extinction of Cocaine Self-Administration Behavior.Pharmaceuticals (Basel, Switzerland) · 2011Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCocaine not only induces intense rewarding sensations but also craving for more cocaine, particularly during abstinence, an effect that contributes, together with other factors, to relapse. Here we sought to prevent this effect by extinguishing the conditioned interoceptive cues of cocaine that are thought to be acquired during repeated cocaine use.
methodsCocaine-induced craving was studied in rats using the well-validated model of drug-primed reinstatement of cocaine seeking. To extinguish the conditioned interoceptive effects of cocaine, rats received daily repeated cocaine priming in the absence of drug reinforcement.
resultsCocaine-primed reinstatement of cocaine seeking dramatically decreased with repeated cocaine priming regardless of the testing dose and even following a history of extended access to cocaine self-administration. The extinction of cocaine-primed reinstatement of cocaine seeking was enduring, generalized to stress-another major trigger of drug craving and relapse-and was context-dependent.
conclusionsThese findings clearly show that it is feasible to prevent the ability of cocaine and stress to induce cocaine seeking using an approach designed to extinguish the drug's conditioned interoceptive cues. Although this preclinical extinction approach has limitations that need to be overcome in future research (i.e., its context-dependency), it may nevertheless represent a promising basis for the development of a novel exposure therapy against cocaine relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.