Evidence map›Paper›PMID 21571254›Full record

ReviewBiological psychiatry2011

Transcranial magnetic stimulation: a neuroscientific probe of cortical function in schizophrenia.

Shawn M McClintock, Catarina Freitas, Lindsay Oberman, Sarah H Lisanby, Alvaro Pascual-Leone

Open access · greenAbstract readReview
In one paragraph

Review in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Vibration stimulation to the lower limbs improves freezing of gait and modifies cortical electrical activities in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
  16. Review
  17. Modulation of motor cortical excitability by continuous theta-burst stimulation in adults with autism spectrum disorder.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Shawn M McClintockBrain Stimulation Laboratory, Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, Texas, USA.
Catarina Freitas
Lindsay Oberman
Sarah H Lisanby
Alvaro Pascual-Leone
Berenson Allen Center for Noninvasive Brain Stimulation · USBeth Israel Deaconess Medical Center · USDuke University Hospital · USNew York Psychoanalytic Society and Institute · USUniversitat Autònoma de Barcelona · ES

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ZINC STATUS AND T CELL DISORDER IN MILD HUMAN ZINC DEFICIENCYM01RR001032 · NCRR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MANTZOROS, CHRISTOS S · 1985 to 2008
$32.3M
Harvard Clinical and Translational Science Center (KL2)KL2RR025757 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$4.1M
Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP)K23MH087739 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI MCCLINTOCK, SHAWN M · 2010 to 2014
$641k
Study and Modulation of Brian PlasticityK24RR018875 · NCRR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PASCUAL-LEONE, ALVARO · 2004 to 2008
$602k
Plasticity in Autism Spectrum Disorders: Magnetic Stimulation StudiesF32MH080493 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI OBERMAN, LINDSAY M · 2007 to 2009
$107k
NCRR NIH HHS 1KL2RR025757-01NCRR NIH HHS K24 RR018875NCRR NIH HHS KL2 RR025757NCRR NIH HHS M01 RR001032NCRR NIH HHS M01 RR01032NCRR NIH HHS UL1 RR025758NIMH NIH HHS F32 MH080493NIMH NIH HHS F32MH080493NIMH NIH HHS K23 MH087739
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) is a neuropsychiatric tool that can serve as a useful method to better understand the neurobiology of cognitive function, behavior, and emotional processing. The purpose of this article is to examine the utility of TMS as a means to measure neocortical function in neuropsychiatric disorders in general, and schizophrenia in particular, for the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia initiative. When incorporating TMS paradigms in research studies, methodologic considerations include technical aspects of TMS, cohort selection and confounding factors, and subject safety. Available evidence suggests benefits of TMS alone or in combination with neurophysiologic and neuroimaging methods, including positron emission tomography, single photon emission computed tomography, magnetic resonance imaging, functional magnetic resonance imaging, functional near infrared spectroscopy, magnetoencephalography, and electroencephalography, to explore neocortical function. With the multiple TMS techniques including single-pulse, paired-pulse, paired associative stimulation, and repetitive TMS and theta burst stimulation, combined with neurophysiologic and neuroimaging methods, there exists a plethora of TMS experimental paradigms to modulate neocortical physiologic processes. Specifically, TMS can measure cortical excitability, intracortical inhibitory and excitatory mechanisms, and local and network cortical plasticity. Coupled with functional and electrophysiologic modalities, TMS can provide insight into the mechanisms underlying healthy neurodevelopment and aging, as well as neuropsychiatric pathology. Thus, TMS could be a useful tool in the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia armamentarium of biomarker methods. Future investigations are warranted to optimize TMS methodologies for this purpose.

Indexed as

BiomarkersBrain MappingCerebral CortexCognitionHumansMental DisordersSchizophreniaTranscranial Magnetic StimulationBiomarkers

Identifiers

PMID21571254
PMCPMC3270326
OpenAlexW2037097587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.